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Liang, Yihuai
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Publications (3 of 3) Show all publications
Liang, Y., Lei, L., Nilsson, J., Li, H., Nordberg, M., Bernard, A., . . . Jin, T. (2012). Renal function after reduction in cadmium exposure: an eight-year follow-up of residents in cadmium-polluted areas. Journal of Environmental Health Perspectives, 120(2), 223-228
Open this publication in new window or tab >>Renal function after reduction in cadmium exposure: an eight-year follow-up of residents in cadmium-polluted areas
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2012 (English)In: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 120, no 2, p. 223-228Article in journal (Refereed) Published
Abstract [en]

Background and objective: Long-term exposure to cadmium (Cd) causes renal dysfunction, but its change with exposure is unknown. We aimed at assessing the evolution of Cd-induced renal effects after a reduction in dietary exposure to Cd in rice.

Methods: 412 residents in previously Cd-polluted and non-polluted areas were examined twice: in 1998 and 2006. Changes in blood Cd, urinary Cd, and kidney function (N-acetyl-β-D-glucosaminidase = NAG, β2-microglobulin, and albumin in urine) were measured. Results: In the most polluted area, mean blood Cd was 8.9 μg/L in 1998 and 3.3 μg/L in 2006, and urinary Cd was 11.6 and 9.0 μg/g creatinine in 1998 and 2006, respectively. Urinary albumin in 1998 increased with urinary Cd but no such exposure-response appeared for 2006 albumin versus urinary Cd 1998, indicating recovery. Other biomarkers of kidney function were also elevated in 1998. Partial recovery was observed for NAG, among women, and suggested for β2-microglobulin, among young individuals. The probability of having a β2-microglobulin above the 95th percentile in 2006 was high in those with an elevated β2-microglobulin in 1998 (odds ratio: 24.8, 95% CI: 11.2-55.3), whereas corresponding estimates for albumin and NAG were 3.0 (1.2-7.5) and 2.6 (1.6-4.4), respectively.

Conclusions: Results suggest that a Cd-mediated increase in urinary albumin excretion is reversible upon substantial reduction of exposure. For the markers of tubular effects, a tendency towards improvement, but not complete recovery, was observed. Data from repeated observations suggests that β2-microglobulin may be more informative than NAG as an indicator for the individual's future tubular function.

Place, publisher, year, edition, pages
National Institute of Environmental Health Sciences, 2012
Keywords
albumin, β2-microglobulin, cadmium, environmental exposure, N-acetyl-β-D-glucosaminidase, renal function.
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-50958 (URN)10.1289/ehp.1103699 (DOI)22027495 (PubMedID)
Available from: 2012-01-02 Created: 2012-01-02 Last updated: 2018-06-08Bibliographically approved
Liang, Y., Li, H., Xiang, C., Lei, L., Jin, T., Nordberg, M. & Nordberg, G. F. (2010). Increased hepatic and decreased urinary metallothionein in rats after cessation of oral cadmium exposure. Basic & Clinical Pharmacology & Toxicology, 106(4), 348-355
Open this publication in new window or tab >>Increased hepatic and decreased urinary metallothionein in rats after cessation of oral cadmium exposure
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2010 (English)In: Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, E-ISSN 1742-7843, Vol. 106, no 4, p. 348-355Article in journal (Refereed) Published
Abstract [en]

We investigated the role of metallothionein (MT) in tissues after cessation of cadmium (Cd) exposure. Wistar rats of both genders were given CdCl(2) in drinking water at daily doses of 0, 2.5, 5.0 or 10.0 mg Cd/kg body-weight for 12 weeks. Half of the animals were then killed; the others were given Cd-free water for the following 16 weeks, i.e. until 28 weeks after start of the experiment (28-week rats). We observed dose-dependent increases in the levels of MT in the tissues of rats 12 weeks after beginning the experiment (12-week rats). After the exposure ceased, levels of MT in the 28-week rats changed in three ways: an increase in the liver, persistence in the kidney cortex and a decrease in the medulla, relative to those levels in their 12-week counterparts. Biomarkers of kidney dysfunction were determined to be urinary MT (UMT) and urinary N-acetyl-beta-d-glucosaminidase (UNAG). After 12 weeks, we observed dose-related statistically significant increases in UMT and UNAG in all of the Cd-exposed groups. A statistically significant decrease for UNAG between the 12- and 28-week rats occurred among males at the lowest Cd dose and for UMT in all of the Cd-exposed groups. The unchanged tissue levels of MT in the kidney cortex suggest that decreased UMT is a sign either of (i) decreased transport of Cd-MT from the liver via blood plasma to the renal tubules or (ii) increased tubular reabsorption and recovery of renal tubular function.

Place, publisher, year, edition, pages
John Wiley & Sons, 2010
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-30720 (URN)10.1111/j.1742-7843.2009.00500.x (DOI)000275531900012 ()20030629 (PubMedID)
Available from: 2010-01-14 Created: 2010-01-14 Last updated: 2018-06-08Bibliographically approved
Liang, Y., Li, H., Lei, L., Yin, T., Nordberg, M. & Nordberg, G. (2008). Immunolocalization of metallothionein in liver and kidney of Wistar rats exposed to cadmium.. Cell Biology and Toxicology, 24(1), 95-6
Open this publication in new window or tab >>Immunolocalization of metallothionein in liver and kidney of Wistar rats exposed to cadmium.
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2008 (English)In: Cell Biology and Toxicology, ISSN 0742-2091, E-ISSN 1573-6822, Vol. 24, no 1, p. 95-6Article in journal (Refereed) Published
Identifiers
urn:nbn:se:umu:diva-30696 (URN)
Available from: 2010-01-13 Created: 2010-01-13 Last updated: 2018-06-08
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