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Marklund, Ingrid
Publications (4 of 4) Show all publications
Idahl, A., Lundin, E., Elgh, F., Jurstrand, M., Møller, J. K., Marklund, I., . . . Ottander, U. (2010). Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, human papillomavirus, and polyomavirus are not detectable in human tissue with epithelial ovarian cancer, borderline tumor, or benign conditions. American Journal of Obstetrics and Gynecology, 202(1), 71.e1-71.e6
Open this publication in new window or tab >>Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, human papillomavirus, and polyomavirus are not detectable in human tissue with epithelial ovarian cancer, borderline tumor, or benign conditions
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2010 (English)In: American Journal of Obstetrics and Gynecology, ISSN 0002-9378, E-ISSN 1097-6868, Vol. 202, no 1, p. 71.e1-71.e6Article in journal (Other academic) Published
Abstract [en]

OBJECTIVE: We sought to analyze the presence of the microorganisms Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, human papillomavirus (HPV), and the polyomaviruses BK virus (BKV) and JC virus (JCV) in ovarian tissues of women with ovarian carcinomas, borderline tumors, and benign conditions. STUDY DESIGN: Ovarian tissue, snap-frozen and stored at -80 degrees C, from 186 women with benign conditions, borderline tumors, and epithelial ovarian cancer, as well as tissue from the contralateral ovary of 126 of these women, were analyzed regarding presence of C trachomatis and N gonorrhoeae (transcription mediated amplification), M genitalium (real-time polymerase chain reaction [PCR]), HPV (PCR), and BKV and JCV (PCR). RESULTS: All the tissue samples studied were found negative for the microorganisms analyzed. CONCLUSION: C trachomatis, M genitalium, N gonorrhoeae, HPV, and the polyomaviruses BKV and JCV are not detectable in ovarian tissues either from women with benign conditions and borderline tumors or from women with ovarian cancer.

Keywords
bacteria, borderline ovarian tumors, infection, ovarian cancer, virus
National Category
Obstetrics, Gynecology and Reproductive Medicine
Research subject
Obstetrics and Gynaecology
Identifiers
urn:nbn:se:umu:diva-22256 (URN)10.1016/j.ajog.2009.07.042 (DOI)000273026200020 ()19766974 (PubMedID)
Note

Originally included in thesis in submitted form with the title "Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, HPV and polyoma virus are not detectable in human tissues of epithelial ovarian cancer, borderline tumors and benign conditions"

Available from: 2009-05-04 Created: 2009-05-04 Last updated: 2018-06-08Bibliographically approved
Bergh, J., Marklund, I., Thellenberg-Karlsson, C., Grönberg, H., Elgh, F. & Alexeyev, O. A. (2007). Detection of Escherichia coli 16S RNA and Cytotoxic Necrotizing Factor 1 Gene in Benign Prostate Hyperplasia.. Eur Urol, 51(2), 457-463
Open this publication in new window or tab >>Detection of Escherichia coli 16S RNA and Cytotoxic Necrotizing Factor 1 Gene in Benign Prostate Hyperplasia.
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2007 (English)In: Eur Urol, ISSN 0302-2838, Vol. 51, no 2, p. 457-463Article in journal (Refereed) Published
Keywords
Escherichia coli, Cytotoxic necrotizing factor, Benign prostate hyperplasia
Identifiers
urn:nbn:se:umu:diva-12224 (URN)doi:10.1016/j.eururo.2006.06.008 (DOI)16904256 (PubMedID)
Available from: 2007-09-18 Created: 2007-09-18 Last updated: 2018-06-09Bibliographically approved
Bergh, J., Marklund, I., Gustavsson, C., Wiklund, F., Grönberg, H., Allard, A., . . . Elgh, F. (2007). No link between viral findings in the prostate and subsequent cancer development. British Journal of Cancer, 96(1), 137-139
Open this publication in new window or tab >>No link between viral findings in the prostate and subsequent cancer development
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2007 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 96, no 1, p. 137-139Article in journal (Refereed) Published
Abstract [en]

In an investigation of 201 prostate tissue samples from patients with benign prostate hyperplasia that later progressed to prostate cancer and 201 matched controls that did not, there were no differences in the prevalence of adenovirus, herpesvirus, papilloma virus, polyoma virus and Candida albicans DNA.

Place, publisher, year, edition, pages
London: Nature Publishing Group, 2007
Keywords
DNA virus, C. albicans, prostate, benign prostate hyperplasia
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-20655 (URN)10.1038/sj.bjc.6603480 (DOI)17117176 (PubMedID)
Available from: 2009-03-24 Created: 2009-03-24 Last updated: 2018-06-09Bibliographically approved
Alexeyev, O., Bergh, J., Marklund, I., Thellenberg Karlsson, C., Wiklund, F., Grönberg, H., . . . Elgh, F. (2006). Association between the presence of bacterial 16S RNA in prostate specimens taken during transurethral resection of prostate and subsequent risk of prostate cancer (Sweden). Cancer Causes and Control, 17(9), 1127-1133
Open this publication in new window or tab >>Association between the presence of bacterial 16S RNA in prostate specimens taken during transurethral resection of prostate and subsequent risk of prostate cancer (Sweden)
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2006 (English)In: Cancer Causes and Control, ISSN 0957-5243, E-ISSN 1573-7225, Vol. 17, no 9, p. 1127-1133Article in journal (Refereed) Published
Abstract [en]

Objective: To study bacterial 16S RNA in archival prostate samples from 352 patients with benign prostate hyperplasia (BPH) and evaluate whether the presence of bacterial DNA was different in those who later developed prostate cancer (n = 171) and in the matched controls that did not progress to cancer (n = 181).

Methods: 16S DNA PCR followed by cloning and sequencing the positive samples.

Results: In 96/352 (27%) of the prostate tissue specimens 16S RNA were detected. Sequence analysis revealed Propionibacterium acnes as the predominant microorganism (23% of 16S RNA positive patients). The second most frequent isolate—Escherichia coli was found in 12 (12%) patients. The other isolates included Pseudomonas sp. (3 patients), Actinomyces sp. (2), Streptococcus mutans (1), Corynebacterium sp. (2),Nocardioides sp. (1), Rhodococcus sp. (1) Veillonella sp. (2). In P. acnes positive samples 62% exhibited severe histological inflammation versus 50% in the bacteria-negative group (p = 0.602). The presence of P. acnes in the prostate was associated with prostate cancer development (OR 2.17, 95% CI 0.77–6.95).

Conclusions: This study has revealed P. acnes as the most common bacteria in the prostate in BPH. Further studies are needed to clarify its role in contributing to the development of prostatic inflammation and prostate cancer.

Place, publisher, year, edition, pages
Dordrecht: Kluwer Academic Publishers, 2006
Keywords
16S RNA, propionibacterium, prostate
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-13555 (URN)10.1007/s10552-006-0054-2 (DOI)
Available from: 2008-02-11 Created: 2008-02-11 Last updated: 2018-06-09Bibliographically approved
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