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Königsson, Johan
Publications (2 of 2) Show all publications
Brenner, P., Granqvist, M., Königsson, J., Al Nimer, F., Piehl, F. & Jokinen, J. (2018). Depression and fatigue in multiple sclerosis: Relation to exposure to violence and cerebrospinal fluid immunomarkers. Psychoneuroendocrinology, 89, 53-58
Open this publication in new window or tab >>Depression and fatigue in multiple sclerosis: Relation to exposure to violence and cerebrospinal fluid immunomarkers
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2018 (English)In: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 89, p. 53-58Article in journal (Refereed) Published
Abstract [en]

Multiple sclerosis (MS) is a neuroinflammatory condition characterized by chronic dysregulation of immune responses leading to repeated episodes of inflammation in the central nervous system. Depression and fatigue are common among MS patients, even in early disease phases, and the disease course can be negatively affected by stressful events. IL-6 and IL-8 have been associated with depression and stressful life events in non-MS patients. The aim of this study was to examine the relationships between depression, fatigue, and exposure to violence, with IL-6 and IL-8 levels in the cerebrospinal fluid (CSF) of MS patients. Levels of IL-6 and -8 were analyzed in the CSF of 47 patients with relapsing-remitting MS. Correlations between IL-6 and IL-8 levels and self-rated depression and fatigue symptoms, as well as clinician-rated history of being exposed to interpersonal violence, were analyzed with correction for age, sex and MS disability status. IL-6 correlated significantly (p < 0.05) with depressive symptoms (adjusted Spearman’s ρ = 0.39), fatigue (ρ = 0.39), and exposure to violence in adult life (ρ = 0.35). Depression correlated with both fatigue and being exposed to violence. Associations were not present among patients exposed to disease modifying drugs. In exploratory analyses, the relationship between exposure to violence and IL-6 was non-significant when controlled for depression. Further research should focus on replication of these results, as well as exploring the impact of stressful life events on immune regulation and the clinical characteristics and prognosis of MS patients.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Multiple sclerosis, Interleukins, Depression, Fatigue, Stress, Disability
National Category
Neurology
Identifiers
urn:nbn:se:umu:diva-151191 (URN)10.1016/j.psyneuen.2018.01.002 (DOI)000430625700008 ()29324301 (PubMedID)2-s2.0-85043391136 (Scopus ID)
Available from: 2018-09-04 Created: 2018-09-04 Last updated: 2018-09-04Bibliographically approved
Jokinen, J., Königsson, J., Moberg, T., Jonsson, E. G., Tiihonen, J., Nordstrom, P., . . . Asberg, M. (2018). Platelet monoamine oxidase activity and interpersonal violence in male suicide attempters. Psychiatry Research, 260, 173-176
Open this publication in new window or tab >>Platelet monoamine oxidase activity and interpersonal violence in male suicide attempters
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2018 (English)In: Psychiatry Research, ISSN 0165-1781, E-ISSN 1872-7123, Vol. 260, p. 173-176Article in journal (Refereed) Published
Abstract [en]

Low platelet monoamine oxidase B (MAO-B) activity, proxy of low central serotonergic functions, has been shown to correlate with criminal behavior in adolescents that come from an unfavorable psychosocial environment but not in adolescents from good conditions, indicating a link between environment, MAO-B activity and aggressive behavior. The purpose of this study was to examine the association between MAO-B activity and lifetime interpersonal violence in suicide attempters. The study included a total of 28 suicide attempters (18 men and 10 women). Assessments of childhood exposure to and expressed interpersonal violence during childhood and as an adult were carried out with the Karolinska Interpersonal Violence Scale (KIVS). Platelet MAO-B activity was measured with 2-phenylethylamine (b-PEA) as substrate. Broken down by gender, the correlations between platelet MAO-B activity and both exposure scores to interpersonal violence as a child and expressed lifetime interpersonal violence were significant in male suicide attempters (r = -0.61, p = 0.035; r = - 0.84, p = 0.0005), but not in women. Our finding of significant associations between interpersonal violence and low MAO-B activity need to be replicated in other cohorts of suicide attempters.

Keywords
MAO-B, Serotonin, Suicide, Violence, Early life adversity
National Category
Psychiatry
Identifiers
urn:nbn:se:umu:diva-145597 (URN)10.1016/j.psychres.2017.11.057 (DOI)000424855300026 ()
Available from: 2018-03-22 Created: 2018-03-22 Last updated: 2019-08-26Bibliographically approved
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