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Dernstedt, Andy
Publications (2 of 2) Show all publications
Kolan, S. S., Lidström, T., Mediavilla, T., Dernstedt, A., Degerman, S., Hultdin, M., . . . Forsell, M. N. E. (2019). Growth-inhibition of cell lines derived from B cell lymphomas through antagonism of serotonin receptor signaling. Scientific Reports, 9, Article ID 4276.
Open this publication in new window or tab >>Growth-inhibition of cell lines derived from B cell lymphomas through antagonism of serotonin receptor signaling
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2019 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, article id 4276Article in journal (Refereed) Published
Abstract [en]

A majority of lymphomas are derived from B cells and novel treatments are required to treat refractory disease. Neurotransmitters such as serotonin and dopamine influence activation of B cells and the effects of a selective serotonin 1A receptor (5HT1A) antagonist on growth of a number of B cell-derived lymphoma cell lines were investigated. We confirmed the expression of 5HT1A in human lymphoma tissue and in several well-defined experimental cell lines. We discovered that the pharmacological inhibition of 5HT1A led to the reduced proliferation of B cell-derived lymphoma cell lines together with DNA damage, ROS-independent caspase activation and apoptosis in a large fraction of cells. Residual live cells were found ‘locked’ in a non-proliferative state in which a selective transcriptional and translational shutdown of genes important for cell proliferation and metabolism occurred (e.g., AKT, GSK-3β, cMYC and p53). Strikingly, inhibition of 5HT1A regulated mitochondrial activity through a rapid reduction of mitochondrial membrane potential and reducing dehydrogenase activity. Collectively, our data suggest 5HT1A antagonism as a novel adjuvant to established cancer treatment regimens to further inhibit lymphoma growth.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-157754 (URN)10.1038/s41598-019-40825-x (DOI)000460924100016 ()30862884 (PubMedID)2-s2.0-85062839295 (Scopus ID)
Available from: 2019-04-08 Created: 2019-04-08 Last updated: 2019-04-08Bibliographically approved
Kerkman, P., Tuiskunen-Bäck, A., Dernstedt, A., Wigren, J., Ahlm, C. & Forsell, M. (2017). The B cell response towards Puumala virus infection: can B cells be infected?. Paper presented at 44th Annual Meeting of the Scandinavian-Society-for-Immunology (SSI), OCT 17-20, 2017, Stockholm, SWEDEN. Scandinavian Journal of Immunology, 86(4), 260-260
Open this publication in new window or tab >>The B cell response towards Puumala virus infection: can B cells be infected?
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2017 (English)In: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 86, no 4, p. 260-260Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
WILEY, 2017
National Category
Immunology
Identifiers
urn:nbn:se:umu:diva-140892 (URN)000411865200034 ()
Conference
44th Annual Meeting of the Scandinavian-Society-for-Immunology (SSI), OCT 17-20, 2017, Stockholm, SWEDEN
Note

Meeting Abstract: A-31234

Available from: 2017-11-20 Created: 2017-11-20 Last updated: 2018-06-09
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