umu.sePublications
Change search
Link to record
Permanent link

Direct link
BETA
Sun, Sun
Publications (5 of 5) Show all publications
Sun, S., Borisenko, O., Spelman, T. & Ahmed, A. R. (2018). Patient Characteristics, Procedural and Safety Outcomes of Bariatric Surgery in England: a Retrospective Cohort Study 2006-2012. Obesity Surgery, 28, 1098-1108
Open this publication in new window or tab >>Patient Characteristics, Procedural and Safety Outcomes of Bariatric Surgery in England: a Retrospective Cohort Study 2006-2012
2018 (English)In: Obesity Surgery, ISSN 0960-8923, E-ISSN 1708-0428, Vol. 28, p. 1098-1108Article in journal (Refereed) Published
Abstract [en]

The objective of the study is to analyze procedural and safety outcomes associated with bariatric surgery and describe the characteristics of patients undertaking bariatric procedures in England between April 2006 and March 2012. This is a retrospective cohort study of all adult patients in England diagnosed with obesity and undergoing bariatric surgery as a primary procedure in NHS-funded sites between April 2006 and March 2012 using data sourced from the Hospital Episode Statistics dataset. Length of stay (LOS), 30-day readmission, and post-surgery complication were analyzed as primary outcomes. Socio-demographic background, provider type, procedure volume, and comorbidities were all analyzed as potential explanatory variables. Gastric bypass (GBP, 12,628) was the most utilized procedure, followed by gastric banding (GB, 6872) and sleeve gastrectomy (SG, 3251). The most prevalent comorbidity was type 2 diabetes (23%). Inpatient mortality was low (≀ 0.15%) for all procedure types. LOS and the risks of both post-operative complication and 30-day readmission were significantly lower for GB, relative to those for GBP and SG. Ethnicity, geographical area, surgery type, and volume were all associated with LOS, risk of readmission, and complication. Provider type and deprivation were further associated with LOS while age correlated with readmission only. An increasing comorbidity burden was associated with an increased risk of both readmission and complication. Gastric bypass was the most frequently reported procedure in England across the observation period. While utilization across all procedure types increased between 2007 and 2010, overall uptake of bariatric surgery in England represents only a small proportion of the eligible population. Readmission and complication rates were lower for gastric banding relative to those for either gastric bypass or sleeve gastrectomy. The observed inpatient mortality rate was low across all procedure types.

Place, publisher, year, edition, pages
Springer, 2018
National Category
Health Sciences
Identifiers
urn:nbn:se:umu:diva-145014 (URN)10.1007/s11695-017-2978-x (DOI)
Funder
Medtronic, Sweden
Available from: 2018-02-16 Created: 2018-02-16 Last updated: 2018-10-29Bibliographically approved
Zhuo, L., Xu, L., Ye, J., Sun, S., Zhang, Y., Burstrom, K. & Chen, J. (2018). Time Trade-Off Value Set for EQ-5D-3L Based on a Nationally Representative Chinese Population Survey. Value in Health, 21(11), 1330-1337
Open this publication in new window or tab >>Time Trade-Off Value Set for EQ-5D-3L Based on a Nationally Representative Chinese Population Survey
Show others...
2018 (English)In: Value in Health, ISSN 1098-3015, E-ISSN 1524-4733, Vol. 21, no 11, p. 1330-1337Article in journal (Refereed) Published
Abstract [en]

Objectives: To obtain a nationally representative Chinese three-level EuroQol five-dimensional questionnaire value set based on the time trade-off (TTO) method.

Methods: A multistage, stratified, clustered random nationally representative Chinese sample was used. The study design followed an adapted UK Measurement and Valuation of Health protocol. Each respondent valued 11 random states plus state 33333 and "unconscious" using the TTO method in face-to-face interviews. Three types of models were explored: ordinary least squares, general least squares, and weighted least squares models.

Results: In total, 5939 inhabitants aged 15 years and older were interviewed. Of these, 5503 satisfactorily interviewed participants were included in constructing models. An ordinary least squares model including 10 dummies without constant and N3 had a mean absolute error of 0.083 and a correlation coefficient of 0.899 between the predicted and mean values. Goodness-of-fit indices of two models based on split subsample were similar.

Conclusions: TTO values were higher in our study compared with those in a study carried out in urban areas, which is mirrored by the higher values in rural areas. Several other aspects, in addition to the valuation procedure, might have influenced the results, such as factors beyond demographic factors such as view on life and death and believing in an afterlife, which need further investigation. Future studies using the three-level EuroQol five-dimensional questionnaire should consider using this value set based on a nationally representative sample of the Chinese population.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
China, EQ-5D-3L, nationally representative sample, time trade-off, value set
National Category
Health Care Service and Management, Health Policy and Services and Health Economy Other Health Sciences
Identifiers
urn:nbn:se:umu:diva-154973 (URN)10.1016/j.jval.2018.04.1370 (DOI)000450111400009 ()30442281 (PubMedID)
Available from: 2019-01-08 Created: 2019-01-08 Last updated: 2019-01-08Bibliographically approved
Du, X., Khamitova, A., Kyhlstedt, M., Sun, S. & Sengoelge, M. (2018). Utilisation of real-world data from heart failure registries in OECD countries: a systematic review. IJC Heart & Vasculature, 19, 90-97
Open this publication in new window or tab >>Utilisation of real-world data from heart failure registries in OECD countries: a systematic review
Show others...
2018 (English)In: IJC Heart & Vasculature, ISSN 2352-9067, Vol. 19, p. 90-97Article, review/survey (Refereed) Published
Abstract [en]

Background: Heart failure represents a major public health issue that impacts 26 million people globally. Currently, real-world data represents a key instrument for providing the verification of both internal and external validity, yet there is still a lack of understanding regarding its scope in complementing evidence of treatments for heart failure. This study aims to increase understanding of the utilisation of real-word data from heart failure registries in Organisation for Economic Co-operation and Development (OECD) countries.

Method: This was a systematic review of existing observational studies from heart failure registries in 35 OECD member countries. Studies from 2000 to March 2017 were identified through electronic databases (MEDLINE (Ovid), EMBASE, Web of Science Core Collection, CINAHL (Ebsco), Cochrane CENTRAL) and appraised according to eligibility criteria.

Results: Two-hundred and two studies met the inclusion criteria, in which the majority were published from 2013 to 2016. All 202 studies were observational, among which 98% were cohort studies (198). The median sample size of all studies was 5152 (2417 to 32,890) and median study period 55 months (33.0 to 72.0). Swedish heart failure registry had the most publications (24, 12%).

Conclusion: Since 2000 there has been an upward trend in the number of published observational studies on heart failure registries in OECD countries with increasingly diverse outcomes and advanced statistical methods to improve their validity and reliability. This indicates that the utilisation of real-world data has experienced a significant upsurge in complementing the findings of clinical trials for improved research of heart failure treatments.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Systematic review, Heart failure, Registry, Real-world data, Observational study, OECD
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-150870 (URN)10.1016/j.ijcha.2018.02.006 (DOI)000436325100018 ()29955668 (PubMedID)2-s2.0-85042942998 (Scopus ID)
Available from: 2018-08-31 Created: 2018-08-31 Last updated: 2018-08-31Bibliographically approved
Bureau, C., Adebayo, D., Chalret de Rieu, M., Elkrief, L., Valla, D., Peck-Radosavljevic, M., . . . Jalan, R. (2017). Alfapump® system vs. large volume paracentesis for refractory ascites: a multicenter randomized controlled study. Journal of Hepatology, 67(5), 940-949
Open this publication in new window or tab >>Alfapump® system vs. large volume paracentesis for refractory ascites: a multicenter randomized controlled study
Show others...
2017 (English)In: Journal of Hepatology, ISSN 0168-8278, E-ISSN 1600-0641, Vol. 67, no 5, p. 940-949Article in journal (Refereed) Published
Abstract [en]

Background and aims: Patients with refractory ascites (RA) require repeated large volume paracenteses (LVP), which involves frequent hospital visits and is associated with a poor quality-of-life. This study assessed safety and efficacy of an automated, low-flow pump (alfapump® [AP]) compared with LVP standard of care [SoC].

Methods: A randomized controlled trial, in seven centers, with six month patient observation was conducted. Primary outcome was time to first LVP. Secondary outcomes included paracentesis requirement, safety, health-related quality-of-life (HRQoL), and survival. Nutrition, hemodynamics, and renal injury biomarkers were assessed in a sub-study at three months.

Results: Sixty patients were randomized and 58 were analyzed (27 AP, 31 SoC, mean age 61.9years, mean MELD 11.7). Eighteen patients were included in the sub-study. Compared with SoC, median time to first LVP was not reached after six months in the AP group, meaning a significant reduction in LVP requirement for the AP patients (AP, median not reached; SoC, 15.0days (HR 0.13; 95%CI 13.0-22.0; p<0.001), and AP patients also showed significantly improved Chronic Liver Disease Questionnaire (CLDQ) scores compared with SoC patients (p<0.05 between treatment arms). Improvements in nutritional parameters were observed for hand-grip strength (p=0.044) and body mass index (p<0.001) in the sub-study. Compared with SoC, more AP patients reported adverse events (AEs; 96.3% vs. 77.4%, p=0.057) and serious AEs (85.2 vs. 45.2%, p=0.002). AEs consisted predominantly of acute kidney injury in the immediate post-operative period, and re-intervention for pump related issues, and were treatable in most cases. Survival was similar in AP and SoC.

Conclusions: The AP system is effective for reducing the need for paracentesis and improving quality of life in cirrhotic patients with RA. Although the frequency of SAEs (and by inference hospitalizations) was significantly higher in the AP group, they were generally limited and did not impact survival.

Lay summary: The alfapump® moves abdominal fluid into the bladder from where it is then removed by urination. Compared with standard treatment, the alfapump reduces the need for large volume paracentesis (manual fluid removal by needle) in patients with medically untreatable ascites. This can improve life quality for these patients.

Keywords
refractory ascites, liver cirrhosis, paracentesis
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-140698 (URN)10.1016/j.jhep.2017.06.010 (DOI)000413027500009 ()28645737 (PubMedID)2-s2.0-85028060813 (Scopus ID)
Available from: 2017-10-17 Created: 2017-10-17 Last updated: 2018-06-18Bibliographically approved
Ren, M., Fang, X., Li, M., Sun, S., Pei, L., Xu, Q., . . . Cao, Y. (2017). Concentration-response relationship between PM2.5 and daily respiratory deaths in China: a systematic review and metaregression analysis of time-series studies. BioMed Research International, Article ID 5806185.
Open this publication in new window or tab >>Concentration-response relationship between PM2.5 and daily respiratory deaths in China: a systematic review and metaregression analysis of time-series studies
Show others...
2017 (English)In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, article id 5806185Article, review/survey (Refereed) Published
Abstract [en]

The association between the particulate matters with aerodynamic diameter <= 2.5.mu m (PM2.5) and daily respiratory deaths, particularly the concentration-response pattern, has not been fully examined and established in China. We conducted a systematic review of time-series studies to compile information on the associations between PM2.5 concentration and respiratory deaths and used metaregression to assess the concentration-response relationship. Out of 1,957 studies screened, eleven articles in English and two articles in Chinese met the eligibility criteria. For single-day lags, per 10 mu g/m(3) increase in PM2.5 concentration was associated with 0.30 [95% confidence interval (CI): 0.10, 0.50] percent increase in daily respiratory deaths; for multiday lags, the corresponding increase in respiratory deaths was 0.69 (95% CI: 0.55, 0.83) percent. Difference in the effects was observed between the northern cities and the south cities in China. No statistically significant concentration-response relationship between PM2.5 concentrations and their effects was found. With increasingly wider location coverage for PM2.5 data, it is crucial to further investigate the concentration-response pattern of PM2.5 effects on respiratory and other cause-specific mortality for the refinement and adaptation of global and national air quality guidelines and targets.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2017
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-141495 (URN)10.1155/2017/5806185 (DOI)000413257500001 ()
Available from: 2017-11-13 Created: 2017-11-13 Last updated: 2018-06-09Bibliographically approved
Organisations

Search in DiVA

Show all publications