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BETA
Chernov, Yevgen A
Alternative names
Publications (3 of 3) Show all publications
Bugaytsova, J. A., Björnham, O., Chernov, Y. A., Gideonsson, P., Henriksson, S., Mendez, M., . . . Boren, T. (2017). Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence. Cell Host and Microbe, 21(3), 376-389
Open this publication in new window or tab >>Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence
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2017 (English)In: Cell Host and Microbe, ISSN 1931-3128, E-ISSN 1934-6069, Vol. 21, no 3, p. 376-389Article in journal (Refereed) Published
Abstract [en]

The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid responsiveness differs among strains; often correlates with different intragastric regions and evolves during chronic infection and disease progression; and depends on pH sensor sequences in BabA and on pH reversible formation of high-affinity binding BabA multimers. We propose that BabA's extraordinary reversible acid responsiveness enables tight mucosal bacterial adherence while also allowing an effective escape from epithelial cells and mucus that are shed into the acidic bactericidal lumen and that bio-selection and changes in BabA binding properties through mutation and recombination with babA-related genes are selected by differences among individuals and by changes in gastric acidity over time. These processes generate diverse H. pylori subpopulations, in which BabA's adaptive evolution contributes to H. pylori persistence and overt gastric disease.

Place, publisher, year, edition, pages
CELL PRESS, 2017
National Category
Microbiology in the medical area Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
urn:nbn:se:umu:diva-132788 (URN)10.1016/j.chom.2017.02.013 (DOI)000396375600023 ()28279347 (PubMedID)
Available from: 2017-05-11 Created: 2017-05-11 Last updated: 2019-05-24Bibliographically approved
Chernov, Y. (2017). Multifaceted adaptation in adherence by the gastric pathogen Helicobacter pylori. (Licentiate dissertation). Umeå: Umeå Universitet
Open this publication in new window or tab >>Multifaceted adaptation in adherence by the gastric pathogen Helicobacter pylori
2017 (English)Licentiate thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Umeå: Umeå Universitet, 2017. p. 41
Keywords
H. pylori, BabA, oligomerization, Leb, recombination, mutation, adherence, pH-sensitive, pH-resistant
National Category
Cell and Molecular Biology
Identifiers
urn:nbn:se:umu:diva-137462 (URN)978-91-7601-733-3 (ISBN)
Available from: 2017-07-05 Created: 2017-07-03 Last updated: 2018-06-09Bibliographically approved
Desai, A., Bugaytsova, J., Chernov, Y. A., Rakhimova, L., Shevtsova, A. & Borén, T.Changes in binding properties of Helicobacter pylori isolated over time from a chronically infected patient.
Open this publication in new window or tab >>Changes in binding properties of Helicobacter pylori isolated over time from a chronically infected patient
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(English)Manuscript (preprint) (Other academic)
National Category
Cell and Molecular Biology
Identifiers
urn:nbn:se:umu:diva-137562 (URN)
Available from: 2017-07-05 Created: 2017-07-05 Last updated: 2018-06-09
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