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Ericsson, M., Sjödin, A. & Burén, J. (2017). Försämrad hjärtfunktion efter fyra veckors intag av lågkolhydrat/högfettkost hos möss: Kan vi lära av translationell forskning?. Svensk kardiologi (1), 33-35
Open this publication in new window or tab >>Försämrad hjärtfunktion efter fyra veckors intag av lågkolhydrat/högfettkost hos möss: Kan vi lära av translationell forskning?
2017 (Swedish)In: Svensk kardiologi, ISSN 1400-5816, no 1, p. 33-35Article in journal (Other (popular science, discussion, etc.)) Published
National Category
Cardiac and Cardiovascular Systems Nutrition and Dietetics
Research subject
Cardiology; Nutrition
Identifiers
urn:nbn:se:umu:diva-135644 (URN)
Available from: 2017-06-01 Created: 2017-06-01 Last updated: 2018-06-09
Nilsson, J., Ericsson, M., Joibari, M. M., Anderson, F., Carlsson, L., Nilsson, S. K., . . . Burén, J. (2016). A low-carbohydrate high-fat diet decreases lean mass and impairs cardiac function in pair-fed female C57BL/6J mice. Nutrition & Metabolism, 13, Article ID 79.
Open this publication in new window or tab >>A low-carbohydrate high-fat diet decreases lean mass and impairs cardiac function in pair-fed female C57BL/6J mice
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2016 (English)In: Nutrition & Metabolism, ISSN 1743-7075, E-ISSN 1743-7075, Vol. 13, article id 79Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Excess body fat is a major health issue and a risk factor for the development of numerous chronic diseases. Low-carbohydrate diets like the Atkins Diet are popular for rapid weight loss, but the long-term consequences remain the subject of debate. The Scandinavian low-carbohydrate high-fat (LCHF) diet, which has been popular in Scandinavian countries for about a decade, has very low carbohydrate content (~5 E %) but is rich in fat and includes a high proportion of saturated fatty acids. Here we investigated the metabolic and physiological consequences of a diet with a macronutrient composition similar to the Scandinavian LCHF diet and its effects on the organs, tissues, and metabolism of weight stable mice.

METHODS: Female C57BL/6J mice were iso-energetically pair-fed for 4 weeks with standard chow or a LCHF diet. We measured body composition using echo MRI and the aerobic capacity before and after 2 and 4 weeks on diet. Cardiac function was assessed by echocardiography before and after 4 weeks on diet. The metabolic rate was measured by indirect calorimetry the fourth week of the diet. Mice were sacrificed after 4 weeks and the organ weight, triglyceride levels, and blood chemistry were analyzed, and the expression of key ketogenic, metabolic, hormonal, and inflammation genes were measured in the heart, liver, and adipose tissue depots of the mice using real-time PCR.

RESULTS: The increase in body weight of mice fed a LCHF diet was similar to that in controls. However, while control mice maintained their body composition throughout the study, LCHF mice gained fat mass at the expense of lean mass after 2 weeks. The LCHF diet increased cardiac triglyceride content, impaired cardiac function, and reduced aerobic capacity. It also induced pronounced alterations in gene expression and substrate metabolism, indicating a unique metabolic state.

CONCLUSIONS: Pair-fed mice eating LCHF increased their percentage of body fat at the expense of lean mass already after 2 weeks, and after 4 weeks the function of the heart deteriorated. These findings highlight the urgent need to investigate the effects of a LCHF diet on health parameters in humans.

Place, publisher, year, edition, pages
BioMed Central, 2016
Keywords
Low-carbohydrate diet, Heart, Mouse
National Category
Clinical Medicine Physiology Nutrition and Dietetics Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-128938 (URN)10.1186/s12986-016-0132-8 (DOI)000388140200001 ()27891164 (PubMedID)
Available from: 2016-12-20 Created: 2016-12-20 Last updated: 2018-06-09Bibliographically approved
Goding, T., Schönmeyr, S. & Burén, J. (2011). Bättre kostvanor nyckel till ökade prestationer. Svensk Idrottsmedicin (2), 26-29
Open this publication in new window or tab >>Bättre kostvanor nyckel till ökade prestationer
2011 (Swedish)In: Svensk Idrottsmedicin, ISSN 1103-7652, no 2, p. 26-29Article in journal (Other (popular science, discussion, etc.)) Published
National Category
Sport and Fitness Sciences Nutrition and Dietetics
Identifiers
urn:nbn:se:umu:diva-135646 (URN)
Available from: 2017-06-01 Created: 2017-06-01 Last updated: 2018-06-09
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0001-5846-9002

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