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Claeson, Anna-Sara
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Publications (10 of 17) Show all publications
Andersson, L., Claeson, A.-S., Dantoft, T. M., Skovbjerg, S., Lind, N. & Nordin, S. (2016). Chemosensory perception, symptoms and autonomic responses during chemical exposure in multiple chemical sensitivity. International Archives of Occupational and Environmental Health, 89(1), 79-88.
Open this publication in new window or tab >>Chemosensory perception, symptoms and autonomic responses during chemical exposure in multiple chemical sensitivity
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2016 (English)In: International Archives of Occupational and Environmental Health, ISSN 0340-0131, E-ISSN 1432-1246, Vol. 89, no 1, 79-88 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: Multiple chemical sensitivity (MCS) is a prevalent medically unexplained symptom characterized by symptom reactions to everyday chemical exposure below hygienic thresholds. The aim of this study was to investigate the expressions of hyper-reactivity in MCS during whole-body exposure to low concentrations of the odorant n-butanol.

Methods: We exposed 18 participants with MCS and 18 non-ill controls to a low concentration of the odorantn-butanol using an exposure chamber. The first 10 min constituted blank exposure, after which then-butanol concentration increased and reached a plateau at 11.5 mg/m3.

Results: MCS participants, compared with controls, reported greater perceived odor intensities, more unpleasantness to the exposure and increasing symptoms over time. MCS participants also expressed higher pulse rate and lower pulse rate variability than controls did. No group differences were found for breathing rate or tonic electrodermal activity responses.

Conclusions: We conclude that MCS sufferers differ from healthy controls in terms of autonomic responses, symptoms and chemosensory perception during chemical exposure.

Place, publisher, year, edition, pages
Springer, 2016
Keyword
Multiple chemical sensitivity, Chemical intolerance, Environmental intolerance, Olfaction, Autonomic rvous system, ROGATIS LR, 1976, BRITISH JOURNAL OF PSYCHIATRY, V128, P280 tthoeft Michael, 2006, JOURNAL OF ABNORMAL PSYCHOLOGY, V115, P397 rie Thi Dao Tran, 2013, INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, V216
National Category
Other Health Sciences
Identifiers
urn:nbn:se:umu:diva-116751 (URN)10.1007/s00420-015-1053-y (DOI)000368807400008 ()25917753 (PubMedID)
Available from: 2016-02-19 Created: 2016-02-11 Last updated: 2017-11-30Bibliographically approved
Lind, N., Nordin, M., Palmquist, E., Claeson, A.-S., Millqvist, E. & Nordin, S. (2015). Coping and Social Support in Asthma and Allergy: The Västerbotten Environmental Health Study. Journal of Asthma, 52(6), 622-629.
Open this publication in new window or tab >>Coping and Social Support in Asthma and Allergy: The Västerbotten Environmental Health Study
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2015 (English)In: Journal of Asthma, ISSN 0277-0903, E-ISSN 1532-4303, Vol. 52, no 6, 622-629 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: Asthma and allergy are stressful conditions that require coping strategies and social support to reduce stress and enhance health-promoting behavior. However, research is limited regarding coping and social support in asthma and allergy. The aim was to better understand use of different coping strategies and perceived social support in low and high severity (exacerbation frequency) of asthma and allergy. Methods: Population-based data were used to provide ratings of coping strategies (Study I) and social support (Study II) from 124 and 94 participants, respectively, with asthma and/or allergy, categorized as low or high in severity. Problem- and emotion-focused coping strategies were assessed as well as emotional, instrumental and informative social support from seven sources. Results: Study I showed that avoiding certain environments (problem-based coping) and trying to accept one’s situation (emotion-based) were the most commonly used coping strategies. These behaviors did not differ due to severity. Study II showed that more emotional than instrumental and informative support was perceived. The highest rated support sources were the partner, family members, and the healthcare system. More social support was reported in low compared to high asthma/allergy severity. Conclusion: The most commonly used coping strategies in the population of persons with these four types of asthma and allergy are avoiding certain environments and trying to accept one’s situation. More emotional support than instrumental and informative is perceived to be received, and most of the support is received from one’s partner and other family members, and least from authorities and patient associations/support groups.

Place, publisher, year, edition, pages
Taylor & Francis, 2015
Keyword
allergic rhinitis, atopic dermatitis, atopy, quality of life, epidemiology
National Category
Respiratory Medicine and Allergy Public Health, Global Health, Social Medicine and Epidemiology Psychology
Identifiers
urn:nbn:se:umu:diva-97461 (URN)10.3109/02770903.2014.991970 (DOI)000361339000015 ()
Available from: 2014-12-18 Created: 2014-12-18 Last updated: 2017-12-05Bibliographically approved
Dantoft, T. M., Skovbjerg, S., Andersson, L., Claeson, A.-S., Lind, N., Nordin, S. & Brix, S. (2015). Inflammatory Mediator Profiling of n-butanol Exposed Upper Airways in Individuals with Multiple Chemical Sensitivity. PLoS ONE, 10(11), Article ID e0143534.
Open this publication in new window or tab >>Inflammatory Mediator Profiling of n-butanol Exposed Upper Airways in Individuals with Multiple Chemical Sensitivity
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2015 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 10, no 11, e0143534Article in journal (Refereed) Published
Abstract [en]

Background Multiple Chemical Sensitivity (MCS) is a chronic condition characterized by reports of recurrent symptoms in response to low level exposure to various chemical substances. Recent findings suggests that dysregulation of the immune system may play a role in MCS pathophysiology. Objectives The aim of this study was to examine baseline and low dose n-butanol-induced upper airway inflammatory response profiles in MCS subjects versus healthy controls. Method Eighteen participants with MCS and 18 age- and sex-matched healthy controls were enrolled in the study. Epithelial lining fluid was collected from the nasal cavity at three time points: baseline, within 15 minutes after being exposed to 3.7 ppm n-butanol in an exposure chamber and four hours after exposure termination. A total of 19 cytokines and chemokines were quantified. Furthermore, at baseline and during the exposure session, participants rated the perceived intensity, valence and levels of symptoms and autonomic recordings were obtained. Results The physiological and psychophysical measurements during the n-butanol exposure session verified a specific response in MCS individuals only. However, MCS subjects and healthy controls displayed similar upper airway inflammatory mediator profiles (P>0.05) at baseline. Likewise, direct comparison of mediator levels in the MCS group and controls after n-butanol exposure revealed no significant group differences. Conclusion We demonstrate no abnormal upper airway inflammatory mediator levels in MCS subjects before or after a symptom-eliciting exposure to low dose n-butanol, implying that upper airways of MCS subjects are functionally intact at the level of cytokine and chemokine production and secretory capacity. This suggests that previous findings of increased cytokine plasma levels in MCS are unlikely to be caused by systemic priming via excessive upper airway inflammatory processes.

National Category
Psychology Clinical Medicine
Identifiers
urn:nbn:se:umu:diva-113858 (URN)10.1371/journal.pone.0143534 (DOI)000365853900139 ()
Available from: 2016-03-13 Created: 2016-01-04 Last updated: 2017-11-30Bibliographically approved
Andersson, L., Claesson, A.-S., Nyberg, L., Stenberg, B. & Nordin, S. (2014). Brain responses to olfactory and trigeminal exposure in idiopathic environmental illness (IEI) attributed to smells: An fMRI study. Journal of Psychosomatic Research, 77(5), 401-408.
Open this publication in new window or tab >>Brain responses to olfactory and trigeminal exposure in idiopathic environmental illness (IEI) attributed to smells: An fMRI study
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2014 (English)In: Journal of Psychosomatic Research, ISSN 0022-3999, E-ISSN 1879-1360, Vol. 77, no 5, 401-408 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Idiopathic environmental intolerance (IEI) to smells is a prevalent medically unexplained illness. Sufferers attribute severe symptoms to low doses of non-toxic chemicals. Despite the label, IEI is not characterized by acute chemical senses. Theoretical models suggest that sensitized responses in the limbic system of the brain constitute an important mechanism behind the symptoms. The aim was to investigate whether and how brain reactions to low-levels of olfactory and trigeminal stimuli differ in individuals with and without IEI. METHODS: Brain responses to intranasally delivered isoamyl acetate and carbon dioxide were assessed in 25 women with IEI and 26 non-ill controls using functional magnetic resonance imaging. RESULTS: The IEI group had higher blood-oxygenated-level-dependent (BOLD) signal than controls in the thalamus and a number of, mainly, parietal areas, and lower BOLD signal in the superior frontal gyrus. The IEI group did not rate the exposures as more intense than the control group did, and there were no BOLD signal differences between groups in the piriform cortex or olfactory regions of the orbitofrontal cortex. CONCLUSIONS: The IEI reactions were not characterized by hyper-responsiveness in sensory areas. The results can be interpreted as a limbic hyperreactivity and speculatively as an inability to inhibit salient extemal stimuli.

Place, publisher, year, edition, pages
Elsevier, 2014
Keyword
idiopathic environmental intolerance, chemical intolerance, multiple chemical sensitivity, fMRI, olfactory, trigeminal
National Category
Psychology Psychiatry
Identifiers
urn:nbn:se:umu:diva-97003 (URN)10.1016/j.jpsychores.2014.09.014 (DOI)000344718200010 ()
Available from: 2014-12-08 Created: 2014-12-08 Last updated: 2017-12-05Bibliographically approved
Glader, A., Claesson, A.-S., Glas, B., Liljelind, I., Eriksson, K., Nyback, M.-H. & Nordin, S. (2014). Byggnadsrelaterad ohälsa : Kompetensutveckling inom hälsovården. Vasa: Novia produktion och publikation (12).
Open this publication in new window or tab >>Byggnadsrelaterad ohälsa : Kompetensutveckling inom hälsovården
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2014 (Swedish)Report (Refereed)
Abstract [sv]

Det finns ett stort behov av utbildning om inomhusmiljö och byggnadsrelaterad ohälsa, både inom ramen för grundläggande yrkesutbildningar och som fortbildningskurser för yrkesverksamma. Hälsoproblem som beror på dålig inomhusluft på arbetsplatsen utreds av företagshälsovården. Dock har de som jobbar inom företagshälsovård idag inte alltid tillräcklig kunskap om inomhusmiljö och byggnadsrelaterad ohälsa och saknar ofta beredskap att som sakkunniga delta i utredningar på arbetsplatser. För att förbättra vården bör personalen utbildas om bl.a. riskfaktorer för dålig inomhusluft, vanliga hälsobesvär och inverkan på arbetsförmåga och produktivitet, de psykosociala faktorernas betydelse samt ansvarsfrågor och hälsoekonomiska konsekvenser. Öppna digitala lärresurser (OER) och kurser på nätet (MOOCs) kan med fördel användas vid fortbildning av vårdpersonal. Nätbaserad utbildning underlättar för vårdpersonalen att själv kunna välja tidpunkt och målsättning. Därtill utgör OER även ett hjälpmedel för att utveckla kunskapsöverföringen mellan Sverige och Finland.

Abstract [en]

There is a growing demand for education on indoor environment and building-related illness, both in the context of basic vocational education and training courses for professionals. Health problems, caused by poor indoor air quality in the workplace, are investigated by the occupational health service. However, those working with occupational health today, do not always have sufficient knowledge about the indoor environment and building-related illness and often lack the capacity to participate as experts in investigations of the indoor environment in a workplace. To improve health care, staff should be trained on e.g. risk factors for poor indoor air quality, common health problems and impact on working capacity and productivity, the impact of psychosocial factors as well as liability issues and health economic implications. Open Educational Resources (OER) and Massive Open Online Courses (MOOCs) can advantageously be used in the training of health professionals. Online education makes it easier for them to choose when to participate and the objectives of the education. Furthermore, OER also constitutes a means to develop knowledge transfer between Sweden and Finland.

Place, publisher, year, edition, pages
Vasa: Novia produktion och publikation, 2014. 18 p.
Series
Serie R: Rapporter, ISSN 1799-4179 ; 12/2014
National Category
Psychology (excluding Applied Psychology)
Identifiers
urn:nbn:se:umu:diva-104968 (URN)978-952-7048-02-3 (ISBN)
Available from: 2015-06-16 Created: 2015-06-16 Last updated: 2015-06-16Bibliographically approved
Palmquist, E., Claeson, A.-S., Neely, G., Stenberg, B. & Nordin, S. (2014). Overlap in prevalence between various types of environmental intolerance. International journal of hygiene and environmental health (Print), 217(4-5), 427-434.
Open this publication in new window or tab >>Overlap in prevalence between various types of environmental intolerance
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2014 (English)In: International journal of hygiene and environmental health (Print), ISSN 1438-4639, E-ISSN 1618-131X, Vol. 217, no 4-5, 427-434 p.Article in journal (Refereed) Published
Abstract [en]

Environmental intolerance (EI) is characterized by attribution of several, multisystem symptoms to specific environmental exposures, such as exposure to odorous/pungent chemicals, certain buildings, electromagnetic fields (EMFs) and everyday sounds. The symptoms are medically unexplained, non-specific and the symptoms overlap between different types of EI. To approach the issue of underlying mechanisms the matter of overlap in prevalence between intolerances can provide valuable information. The aim of the study was to examine if the overlap between intolerance to odorous/pungent chemicals, certain buildings, EMFs and sounds is larger than the expected overlap if no association would exist between them. The study was using cross-sectional data from the Västerbotten Environmental Health Study in Sweden; a large questionnaire-based survey. 8520 adults (18-79 years) were randomly selected after stratification for age and sex, of whom 3406 (40%) participated. Individuals with the four types of intolerance were identified either through self-report, or by having been physician-diagnosed with a specific EI. The overlaps between the four EIs were greater than predictions based on coincidence for both self-reported and diagnosed cases (except for the overlap between diagnosed intolerance to sounds and EMFs). The results raise the question whether different types of EI share similar underlying mechanisms, or at least that the sufferers of EI share some predisposition to acquire the conditions.

Place, publisher, year, edition, pages
Elsevier, 2014
Keyword
prevalence, environmental intolerance, multiple chemical sensitivity, noise sensitivity, sick building syndrome, overlap
National Category
Medical and Health Sciences Infectious Medicine Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-84580 (URN)10.1016/j.ijheh.2013.08.005 (DOI)000335113500001 ()24029726 (PubMedID)
Available from: 2014-01-09 Created: 2014-01-09 Last updated: 2018-01-11Bibliographically approved
Nordin, S., Claeson, A.-S., Andersson, M., Sommar, L., Andree, J., Lundqvist, K. & Andersson, L. (2013). Impact of Health-Risk Perception on Odor Perception and Cognitive Performance. Chemosensory Perception, 6(4), 190-197.
Open this publication in new window or tab >>Impact of Health-Risk Perception on Odor Perception and Cognitive Performance
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2013 (English)In: Chemosensory Perception, ISSN 1936-5802, Vol. 6, no 4, 190-197 p.Article in journal (Refereed) Published
Abstract [en]

Indications of adverse effects of nontoxic malodorous chemical exposure on work performance and safety and the role of health-risk perception on odor perception motivated the present study of the impact of health-risk perception on odor perception and cognitive performance. Healthy young adults were informed that they were to be exposed to an odorous substance that is either potentially health-enhancing (positive information bias, n = 24) or hazardous (negative information bias, n = 25). The two groups, screened for loss in odor-detection sensitivity, were matched for age, sex, chemical intolerance, and negative affectivity. During each of 14 trials of exposure to 433 mg/m(3) of n-butanol, the participants rated the intensity and valence of odor perception and performed a cognitive task that taxed working memory and attention. The results showed that the negative-bias group rated the odor perception as more unpleasant than did the positive-bias group during the entire session, but significantly more unpleasant only during the first half of the session. The negative-bias group was also found to perform significantly poorer on the cognitive task during both halves of the session. No effect of information bias was found on perceived odor intensity. The results provide experimental support for the hypotheses that belief that exposure to an odorous chemical is hazardous contributes to the odor perception being more unpleasant and to poorer cognitive performance.

Keyword
Indoor air quality, Information bias, Odor hedonics, Odor intensity, Olfaction
National Category
Psychology Neurosciences
Identifiers
urn:nbn:se:umu:diva-84101 (URN)10.1007/s12078-013-9153-0 (DOI)000327083500004 ()
Available from: 2013-12-18 Created: 2013-12-16 Last updated: 2018-01-11Bibliographically approved
Nordin, S., Palmquist, E. & Claeson, A.-S. (2013). Metric properties and normative data for brief noise and electromagnetic field sensitivity scales. Scandinavian Journal of Public Health, 41(3), 293-301.
Open this publication in new window or tab >>Metric properties and normative data for brief noise and electromagnetic field sensitivity scales
2013 (English)In: Scandinavian Journal of Public Health, ISSN 1403-4948, E-ISSN 1651-1905, Vol. 41, no 3, 293-301 p.Article in journal (Refereed) Published
Abstract [en]

Aims: Lack of brief questionnaire instruments for quantifying affective reactions to and behavioral disruptions attributed to sounds and electromagnetic fields (EMFs) motivated the present development and metric evaluation of such instruments, called the 11-item Noise Sensitivity Scale (NSS-11) and the 11-item Electromagnetic Field Sensitivity Scale (EMFSS-11). Another objective was to establish normative data for these instruments. Method: Data from 3406 individuals who took part in the Vasterbotten Environmental Health Study was used. The participants constitute a random sample of inhabitants in the county of Vasterbotten in Sweden, aged 18 to 79 years, stratified for age and gender. The participants responded to the NSS-11 and EMFSS-11 and to additional questions for evaluation of concurrent validity. Results: The results show satisfying reliability (Cronbach alpha = 0.71-0.85, varying with age group and gender), concurrent validity, and unidimensionality of the NSS-11 and EMFSS-11, and that the scales generate scores with approximately normal distributions, irrespective of age group and gender. Mean scores, standard deviations, and confidence intervals constitute normative data. Conclusions: The favorable metric properties of the NSS-11 and EMFSS-11 in combination with their fast usage suggest that they are particularly useful for assessment in epidemiological studies, and have the advantage of available normative data.

Keyword
Environmental hypersensitivity, hyperacusis, idiopathic environmental intolerance, normality, psychometrics
National Category
Psychology
Identifiers
urn:nbn:se:umu:diva-73083 (URN)10.1177/1403494813475532 (DOI)000318632100010 ()
Available from: 2013-06-17 Created: 2013-06-17 Last updated: 2017-12-06Bibliographically approved
Nordin, S., Körning Ljungberg, J., Claeson, A.-S. & Neely, G. (2013). Stress and odor sensitivity in persons with noise sensitivity. Noise & Health, 15(64), 173-177.
Open this publication in new window or tab >>Stress and odor sensitivity in persons with noise sensitivity
2013 (English)In: Noise & Health, ISSN 1463-1741, E-ISSN 1998-4030, Vol. 15, no 64, 173-177 p.Article in journal (Refereed) Published
Abstract [en]

Previous research has indicated that sensory sensitivity/intolerance to a specific modality may be part of a more general environmental hypersensitivity, and possibly mediated by stress. This study investigated the relationship between noise sensitivity, perceived stress, and odor sensitivity in a group of men. A quasi-experimental design was used. One-hundred and thirty-four male undergraduate students completed Weinsteins noise sensitivity scale from which a low-sensitivity group (n = 16) and a high-sensitivity (n = 16) group were formed. These two groups were screened for loss in auditory and olfactory detection sensitivity, and completed the perceived stress questionnaire (PSQ) and the chemical sensitivity scale (CSS). One-way analysis of variance and Spearman correlational analyses were performed. Significantly higher scores on the PSQ (P < 0.05) and the CSS (P < 0.05) were found in the high noise-sensitivity group compared to the low noise-sensitivity group. These findings raise the question of whether the relation between noise and odor sensitivity reflects a general environmental sensitivity.

Keyword
Chemical sensitivity, environmental annoyance, hypersensitivity, olfaction, sound
National Category
Psychology
Identifiers
urn:nbn:se:umu:diva-76812 (URN)10.4103/1463-1741.112366 (DOI)000320063000004 ()
Available from: 2013-07-16 Created: 2013-07-15 Last updated: 2017-12-06Bibliographically approved
Nordin, S., Palmquist, E., Claeson, A.-S. & Stenberg, B. (2013). The environmental hypersensitivity symptom inventory: metric properties and normative data from a population-based study. Archives of Public Health, 71(18), 1-10.
Open this publication in new window or tab >>The environmental hypersensitivity symptom inventory: metric properties and normative data from a population-based study
2013 (English)In: Archives of Public Health, ISSN 0778-7367, E-ISSN 2049-3258, Vol. 71, no 18, 1-10 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: High concomitant intolerance attributed to odorous/pungent chemicals, certain buildings, electromagnetic fields (EMF), and everyday sounds calls for a questionnaire instrument that can assess symptom prevalence in various environmental intolerances. The Environmental Hypersensitivity Symptom Inventory (EHSI) was therefore developed and metrically evaluated, and normative data were established. The EHSI consists of 34 symptom items, requires limited time to respond to, and provides a detailed and broad description of the individual's symptomology.

METHODS: Data from 3406 individuals who took part in the Vasterbotten Environmental Health Study were used. The participants constitute a random sample of inhabitants in the county of Vasterbotten in Sweden, aged 18 to 79 years, stratified for age and gender.

RESULTS: Exploratory factor analysis identified five significant factors: airway symptoms (9 items; Kuder-Richardson Formula 20 coefficient, KR-20, of internal consistency = 0.74), skin and eye symptoms (6 items; KR-20 = 0.60), cardiac, dizziness and nausea symptoms (4 items; KR-20 = 0.55), head-related and gastrointestinal symptoms (5 items; KR-20 = 0.55), and cognitive and affective symptoms (10 items; KR-20 = 0.80). The KR-20 was 0.85 for the entire 34-item EHSI. Symptom prevalence rates in percentage for having the specific symptoms every week over the preceding three months constitute normative data.

CONCLUSIONS: The EHSI can be recommended for assessment of symptom prevalence in various types of environmental hypersensitivity, and with the advantage of comparing prevalence rates with normality.

Place, publisher, year, edition, pages
BioMed Central Ltd., 2013
Keyword
Chemical intolerance, Electromagnetic fields, Hyperacusis, Idiopathic environmental intolerance, Prevalence, Sick building syndrome
National Category
Psychology
Identifiers
urn:nbn:se:umu:diva-81475 (URN)10.1186/0778-7367-71-18 (DOI)
Available from: 2013-10-13 Created: 2013-10-13 Last updated: 2017-12-06Bibliographically approved
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