umu.sePublications
Change search
Link to record
Permanent link

Direct link
BETA
Bosson, Jenny A.
Alternative names
Publications (10 of 45) Show all publications
Mobarrez, F., Antoniewicz, L., Hedman, L., Bosson, J. A. & Lundbäck, M. (2020). Electronic cigarettes containing nicotine increase endothelial and platelet derived extracellular vesicles in healthy volunteers. Atherosclerosis
Open this publication in new window or tab >>Electronic cigarettes containing nicotine increase endothelial and platelet derived extracellular vesicles in healthy volunteers
Show others...
2020 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND AND AIMS: E-cigarette use is increasingly common. Whether e-cigarettes are harmful to human health is an intensely debated subject. In order to investigate whether e-cigarettes with and without nicotine cause different vascular responses, we obtained blood samples from healthy young volunteers who performed brief active e-cigarette inhalations. Extracellular vesicles (EVs) of endothelial and platelet origin were measured to determine vascular changes.

METHODS: Using a randomized, double-blind, crossover design, 17 healthy occasional smokers inhaled 30 puffs of e-cigarette vapor during 30 min. Blood samples were collected at baseline, as well as at 0, 2, 4 and 6 h post-exposure. EVs from platelets and endothelial cells were measured by flow cytometry.

RESULTS: Platelet and endothelial derived EVs were significantly increased with peak levels seen at 4 h following exposure to active inhalation of e-cigarette vapor with nicotine. Moreover, platelet derived EVs, expressing platelet activation marker P-selectin and the inflammation marker, CD40 ligand, were also significantly increased following inhalation of e-cigarette vapor with nicotine. In addition, platelet derived EVs expressing CD40 ligand was increased after inhalation of e-cigarette vapor without nicotine.

CONCLUSION: As few as 30 puffs of nicotine-containing e-cigarette vapor caused an increase in levels of circulating EVs of endothelial and platelet origin, which may signify underlying vascular changes. Although e-cigarette vapor without nicotine caused an increase in platelet EVs expressing CD40 ligand, nicotine, as a component in the vapor, seems to have a more compelling effect on extracellular vesicle formation and protein composition.

Place, publisher, year, edition, pages
Elsevier, 2020
Keywords
Electronic cigarette, Endothelial microvesicles, Extracellular vesicles, Microparticles, Platelet microvesicles, e-cigarette
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:umu:diva-168670 (URN)10.1016/j.atherosclerosis.2020.02.010 (DOI)32122618 (PubMedID)
Available from: 2020-03-05 Created: 2020-03-05 Last updated: 2020-03-05
Antoniewicz, L., Brynedal, A., Hedman, L., Lundbäck, M. & Bosson, J. A. (2019). Acute Effects of Electronic Cigarette Inhalation on the Vasculature and the Conducting Airways. Cardiovascular Toxicology, 19(5), 441-450
Open this publication in new window or tab >>Acute Effects of Electronic Cigarette Inhalation on the Vasculature and the Conducting Airways
Show others...
2019 (English)In: Cardiovascular Toxicology, ISSN 1530-7905, E-ISSN 1559-0259, Vol. 19, no 5, p. 441-450Article in journal (Refereed) Published
Abstract [en]

The use of electronic cigarettes has increased exponentially since its introduction onto the global market in 2006. However, short- and long-term health effects remain largely unknown due to the novelty of this product. The present study examines the acute effects of e-cigarette aerosol inhalation, with and without nicotine, on vascular and pulmonary function in healthy volunteers. Seventeen healthy subjects inhaled electronic cigarette aerosol with and without nicotine on two separate occasions in a double-blinded crossover fashion. Blood pressure, heart rate, and arterial stiffness measured by pulse wave velocity and pulse wave analysis were assessed at baseline, and then at 0 h, 2 h, and 4 h following exposure. Dynamic spirometry and impulse oscillometry were measured following vascular assessments at these time points, as well as at 6 h following exposure. e-Cigarette aerosol with nicotine caused a significant increase in heart rate and arterial stiffness. Furthermore, e-cigarette aerosol-containing nicotine caused a sudden increase in flow resistance as measured by impulse oscillometry, indicating obstruction of the conducting airways. Both aerosols caused an increase in blood pressure. The present study indicates that inhaled e-cigarette aerosol with nicotine has an acute impact on vascular and pulmonary function. Thus, chronic usage may lead to long-term adverse health effects. Further investigation is warranted.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019
Keywords
Arterial stiffness, Augmentation index, ENDS, Electronic cigarettes, IOS, Pulse wave velocity, e-Cig
National Category
Occupational Health and Environmental Health Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-158824 (URN)10.1007/s12012-019-09516-x (DOI)000486337400006 ()30963443 (PubMedID)
Available from: 2019-05-09 Created: 2019-05-09 Last updated: 2019-11-11Bibliographically approved
Muala, A., Österdahl, R., Sehlstedt, M., Rankin, G., Pourazar, J., Bosson, J. A., . . . Öhberg, F. (2019). Small airways effects of exposure to wood smoke. Paper presented at European-Respiratory-Society (ERS) International Congress, Madrid, SPAIN, SEP 28-OCT 02, 2019.. European Respiratory Journal, 54
Open this publication in new window or tab >>Small airways effects of exposure to wood smoke
Show others...
2019 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 54Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Sheffield: European Respiratory Society Journals, 2019
Keywords
Asthma, Air pollution
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:umu:diva-168166 (URN)10.1183/13993003.congress-2019.PA2829 (DOI)000507372403325 ()
Conference
European-Respiratory-Society (ERS) International Congress, Madrid, SPAIN, SEP 28-OCT 02, 2019.
Available from: 2020-03-17 Created: 2020-03-17 Last updated: 2020-03-17Bibliographically approved
Rankin, G. D., Wingfors, H., Uski, O., Hedman, L., Ekstrand-Hammarström, B., Bosson, J. & Lundbäck, M. (2019). The toxic potential of a fourth-generation E-cigarette on human lung cell lines and tissue explants. Journal of Applied Toxicology, 39(8), 1143-1154
Open this publication in new window or tab >>The toxic potential of a fourth-generation E-cigarette on human lung cell lines and tissue explants
Show others...
2019 (English)In: Journal of Applied Toxicology, ISSN 0260-437X, E-ISSN 1099-1263, Vol. 39, no 8, p. 1143-1154Article in journal (Refereed) Published
Abstract [en]

The use of electronic cigarettes (E‐cigs) is rapidly increasing. The latest generation of E‐cigs is highly customizable, allowing for high heating coil temperatures. The aim of this study was to assess the toxic potential of a fourth‐generation E‐cig. Aerosols generated from E‐liquid with (24 mg/mL) and without nicotine, using a fourth‐generation E‐cig, were chemically analysed and compared with cigarette smoke (K3R4F). Human lung epithelial cell lines and distal lung tissue explants were exposed to E‐cig vapour extract (EVE) and cigarette smoke extract for 24 hours and assessed for viability, inflammation, oxidative stress and genotoxicity. E‐cig aerosols contained measurable levels of volatile organic compounds, aldehydes and polycyclic aromatic hydrocarbons, in general, to a much lesser extent than cigarette smoke. Higher levels of certain carbonyls, e.g. formaldehyde, were detected in the E‐cig aerosols. EVEs decreased cell viability of BEAS‐2B cells, whereas little effect was seen in A549 cells and distal lung tissue. The nicotine‐containing EVE caused a greater decrease in cell viability and significant increase in DNA damage than the nicotine‐free EVE. Increased cytotoxicity, reactive oxygen species production and genotoxicity were seen with cells and tissue exposed to cigarette smoke extract compared with EVEs. Although E‐cig aerosols were less toxic than cigarette smoke, it was not benign. Moreover, the EVE containing nicotine was more toxic than the nicotine‐free EVE. More research is needed on the short‐ and long‐term health effects of vaping and the usage of newly emerging E‐cig devices to evaluate better the potential negative effects of E‐cigs on human health.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019
Keywords
A549, BEAS-2B, DNA damage, aerosol characterization, cell cycle, electronic cigarette extract, human distal lung tissue, inflammatory cytokines, viability
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-158814 (URN)10.1002/jat.3799 (DOI)000475406700006 ()30957912 (PubMedID)2-s2.0-85063979647 (Scopus ID)
Available from: 2019-05-09 Created: 2019-05-09 Last updated: 2019-08-12Bibliographically approved
Bosson, J. A., Mudway, I. S. & Sandström, T. (2019). Traffic-related Air Pollution, Health, and Allergy: The Role of Nitrogen Dioxide. American Journal of Respiratory and Critical Care Medicine, 200(5), 523-524
Open this publication in new window or tab >>Traffic-related Air Pollution, Health, and Allergy: The Role of Nitrogen Dioxide
2019 (English)In: American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, E-ISSN 1535-4970, Vol. 200, no 5, p. 523-524Article in journal, Editorial material (Other academic) Published
Place, publisher, year, edition, pages
AMER THORACIC SOC, 2019
Keywords
SHORT-TERM EXPOSURE, HOSPITAL ADMISSIONS, CHALLENGE, IGE
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:umu:diva-164510 (URN)10.1164/rccm.201904-0834ED (DOI)000484033400003 ()31059649 (PubMedID)
Available from: 2019-11-20 Created: 2019-11-20 Last updated: 2019-11-20Bibliographically approved
Hansson, A., Rankin, G., Uski, O., Sehlstedt, M., Bosson, J. A., Pourazar, J., . . . Muala, A. (2019). Wood smoke effects on epithelial cell lines and human airway cells. Paper presented at European-Respiratory-Society (ERS) International Congress, Madrid, SPAIN, SEP 28-OCT 02, 2019.. European Respiratory Journal, 54
Open this publication in new window or tab >>Wood smoke effects on epithelial cell lines and human airway cells
Show others...
2019 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 54Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
European Respiratory Society Journals, 2019
Keywords
Bronchoscopy, Immunology, Air pollution
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:umu:diva-168169 (URN)10.1183/13993003.congress-2019.PA5448 (DOI)000507372407158 ()
Conference
European-Respiratory-Society (ERS) International Congress, Madrid, SPAIN, SEP 28-OCT 02, 2019.
Note

Supplement: 63. Meeting Abstract: PA5448.

Available from: 2020-03-17 Created: 2020-03-17 Last updated: 2020-03-17Bibliographically approved
Lundback, M., Mobarrez, F., Antoniewicz, L. & Bosson, J. A. (2018). Acute effects of e-cigarette inhalation with or without nicotine on levels of microvesicles in the blood of human volunteers. Paper presented at 28th International Congress of the European-Respiratory-Society (ERS), SEP 15-19, 2018, Paris, FRANCE. European Respiratory Journal, 52
Open this publication in new window or tab >>Acute effects of e-cigarette inhalation with or without nicotine on levels of microvesicles in the blood of human volunteers
2018 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Background: The e-cigarette use has increased dramatically. Our group has demonstrated signs of possible vascular damage following e-cigarette use.

We study the effects of e-cigarette inhalation (vaping) on vascular function, inflammation and hemostasis. Microvesicles (MV) of endothelial, leukocyte and platelet origin is measured in blood. MV are biomarkers that reflect cell function and can be used when assessing the risk of cardiovascular complications. We have recently shown that cigarette smoking causes an acute increase in MV in blood of healthy volunteers, suggesting vascular injury, inflammation and negative impact on hemostasis. We now investigate if the e-cigarette has similar effects.

Methods: Seventeen healthy sporadic smokers vaped 30 puffs from an e-cigarette with and without nicotine in a crossover fashion. Blood sampling was performed at 0, 2, 4 and 6 hours following exposures. MVs was determined by flow cytometry and measured from platelets (PMV), leukocytes (LMV) and endothelial cells (EMV).

Results: Inhalation of e-cigarettes containing nicotine caused a significant increase in PMV and EMV over time. PMV that exposed P-selectin and/or CD40L increased significantly as well. Nicotine free e-cigarette vapour did not cause a significant increase in PMV and EMV over time.

Discussion: As little as 30 puffs of nicotine containing e-cigarette vapor cause increased levels of circulating MVs of endothelial and platelet origin, indicating possible vascular injury. This may lead to increased progression of atherosclerosis, the underlying cause of myocardial infarction and stroke.

Place, publisher, year, edition, pages
European Respiratory Society, 2018
Identifiers
urn:nbn:se:umu:diva-155992 (URN)10.1183/13993003.congress-2018.PA1725 (DOI)000455567102134 ()
Conference
28th International Congress of the European-Respiratory-Society (ERS), SEP 15-19, 2018, Paris, FRANCE
Note

Supplement: 62

Meeting Abstract: PA1725

Available from: 2019-02-07 Created: 2019-02-07 Last updated: 2019-02-07Bibliographically approved
Hedman, L., Backman, H., Stridsman, C., Bosson, J. A., Lundbäck, M., Lindberg, A., . . . Ekerljung, L. (2018). Association of Electronic Cigarette Use With Smoking Habits, Demographic Factors, and Respiratory Symptoms. JAMA NETWORK OPEN, 1(3), Article ID e180789.
Open this publication in new window or tab >>Association of Electronic Cigarette Use With Smoking Habits, Demographic Factors, and Respiratory Symptoms
Show others...
2018 (English)In: JAMA NETWORK OPEN, ISSN 2574-3805, Vol. 1, no 3, article id e180789Article in journal (Refereed) Published
Abstract [en]

IMPORTANCE There is an ongoing debate about whether electronic cigarettes (e-cigarettes) are the solution to the tobacco epidemic or a new public health threat. Large representative studies are needed to study e-cigarette use in the general population, but hardly any have been published. OBJECTIVES To estimate the prevalence of e-cigarette use and to investigate the association of e-cigarette use with smoking habits, demographic factors, and respiratory symptoms. DESIGN, SETTING, AND PARTICIPANTS Cross-sectional, population-based study of random samples of the population, performed within the Obstructive Lung Disease in Northern Sweden (OLIN) study and West Sweden Asthma Study (WSAS). The same validated questionnaire including identical questions was used in OLIN and WSAS. In 2016, OLIN and WSAS conducted postal questionnaire surveys in random samples of adults aged 20 to 75 years. In OLIN, 6519 participated (response rate, 56.4%); in WSAS, 23 753 participated (response rate, 50.1%). MAIN OUTCOMES AND MEASURES Electronic cigarette use, smoking habits, and respiratory symptoms. RESULTS Of 30 272 participants (16 325 women [53.9%]). 3897 (12.9%) were aged 20 to 29 years; 4242 (14.0%). 30 to 39 years; 5082 (16.8%). 40 to 49 years; 6052 (20.0%), 50 to 59 years; 6628 (21.9%), 60 to 69 years; and 4371(14.4%), 70 to 75 years. The number of current smokers was 3694 (12.3%), and 7305 (24.4%) were former smokers. The number of e-cigarette users was 529 (2.0%). and e-cigarette use was more common among men (275 of 12 347 [2.2%; 95% CI, 2.0%-2.5%]) than women (254 of 14 022 [1.8%; 95% CI, 1.6%-2.0%]). Among current smokers. 350 of 3566 (9.8%; 95% CI, 8.8%10.8%) used e-cigarettes compared with 79 of 6875 (1.1%; 95% CI, 0.9%-1.3%) in former smokers and 96 of 15 832 (0.6%; 95% CI, 0.5%-0.7%) in nonsmokers (P < .001). Among e-cigarette users who answered the survey question about cigarette-smoking habits (n = 525). 350 (66.7%; 95% CI, 62.7%-70.7%) were current smokers, 79 (15.0%; 95% CI, 11.9%-18.1%) were former smokers, and 96 (18.3%; 95% CI, 15.0%-21.6%) were nonsmokers (P < .001 for trend). In a regression analysis, e-cigarette use was associated with male sex (odds ratio [OR], 1.35; 95% CI. 1.12-1.62); age groups 20 to 29 years (OR. 2.77; 95% CI, 1.90-4.05), 30 to 39 years (OR, 2.27; 95% CI, 1.53-3.36), 40 to 49 years (OR, 1.65; 95% CI, 1.11-2.44). and 50 to 59 years (OR, 1.47; 95% CI, 1.01-2.12); educational level at primary school (OR, 1.99; 95% CI, 1.51-2.64) and upper secondary school (OR, 1.57; 95% CI, 1.25-1.96); former smoking (OR. 2.37; 95% CI, 1.73-3.24); and current smoking (OR. 18.10; 95% CI, 14.19-23.09). All respiratory symptoms were most common among dual users and former smokers and nonsmokers who used e-cigarettes. CONCLUSIONS AND RELEVANCE Use of e-cigarettes was most common among smokers, and dual users had the highest prevalence of respiratory symptoms. On a population level, this study indicates that the present use of e-cigarettes does not adequately serve as a smoking cessation tool.

Place, publisher, year, edition, pages
American Medical Association, 2018
National Category
Public Health, Global Health, Social Medicine and Epidemiology Substance Abuse
Identifiers
urn:nbn:se:umu:diva-154863 (URN)10.1001/jamanetworkopen.2018.0789 (DOI)000452641400010 ()
Available from: 2019-01-03 Created: 2019-01-03 Last updated: 2019-01-03Bibliographically approved
Antoniewicz, L., Novo, M., Bosson, J. A. & Lundbäck, M. (2018). Brief exposure to Swedish snus causes divergent vascular responses in healthy male and female volunteers. PLoS ONE, 13(4), Article ID e0195493.
Open this publication in new window or tab >>Brief exposure to Swedish snus causes divergent vascular responses in healthy male and female volunteers
2018 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 4, article id e0195493Article in journal (Refereed) Published
Abstract [en]

Introduction: The use of Swedish oral moist snuff, known as snus, has for a long time been limited to the Scandinavian countries. With declining cigarette sales in the western world, tobacco companies have looked to the development of alternative tobacco products. In 2006 snus products were launched in the US. Even though several studies have demonstrated negative health effects, snus is often depicted as harmless.

The aim of the present study was to investigate acute vascular effects of snus as measured by arterial stiffness as well as blood pressure and heart rate.

Methods: Two separate randomized double-blind crossover studies with the same study design were pooled for analysis. Twenty-nine healthy snus-users (17 females, 12 males) were included. Snus (Göteborgs Rapé) and tobacco free snus (Onico) were administered in a randomized order at two separate visits. Arterial stiffness, blood pressure and heart rate were measured at baseline as well as every five minutes for 40 minutes during exposure. Following snus removal, measurements continued for 30 minutes post exposure. Arterial stiffness was measured using pulse wave velocity (Vicorder) and pulse wave analysis (Sphygmocor).

Results: Compared to placebo, snus significantly increased systolic and diastolic blood pressure as well as heart rate, however, only in females (p = 0.004, p = 0.006 and p<0.001 respectively). No changes were seen in arterial stiffness measurements in either gender.

Conclusion: We observed an increase in blood pressure and heart rate only in females, but not in males due to snus usage as compared to placebo. This novel finding was surprising and needs to be further investigated considering most of the earlier studies have mainly focused on male snus users and the increasing usage of snus among females.

Place, publisher, year, edition, pages
PUBLIC LIBRARY SCIENCE, 2018
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-151174 (URN)10.1371/journal.pone.0195493 (DOI)000430290200044 ()29668699 (PubMedID)2-s2.0-85045611591 (Scopus ID)
Available from: 2018-09-05 Created: 2018-09-05 Last updated: 2019-05-21Bibliographically approved
Uski, O., Rankin, G., Lindgren, R., Lopez, N., Blomberg, A., Muala, A., . . . Sandström, T. (2018). In vitro toxicity of particulate matter derived from biomass cook stoves used in developing countries. Paper presented at International Conference of the American-Thoracic-Society, MAY 18-23, 2018, San Diego, CA. American Journal of Respiratory and Critical Care Medicine, 197
Open this publication in new window or tab >>In vitro toxicity of particulate matter derived from biomass cook stoves used in developing countries
Show others...
2018 (English)In: American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, E-ISSN 1535-4970, Vol. 197Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
American Thoraric Society, 2018
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:umu:diva-154090 (URN)000449978902089 ()
Conference
International Conference of the American-Thoracic-Society, MAY 18-23, 2018, San Diego, CA
Funder
Forte, Swedish Research Council for Health, Working Life and WelfareSwedish Heart Lung Foundation
Available from: 2018-12-12 Created: 2018-12-12 Last updated: 2018-12-12Bibliographically approved
Organisations

Search in DiVA

Show all publications