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Title [sv]
Gener i karies och parodontit-GLIDE konsortiet
Title [en]
Gene discovery in periodontitis and dental caries - the GLIDE consortium
Abstract [sv]
Complex diseases manifest through complex interactions of genetic and environmental risk factors. Defining the nature of the interactions strengthens understanding of pathophysiology and aids in disease prevention through stratified intervention. Periodontitis and dental caries impose an extra-ordinary burden of morbidity and economic stress at an individual and societal level. Both diseases may also impact cardiovascular and metabolic disease risk. Data consolidated under the banner of the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium will be used to (i) discover and validate genetic risk factors for periodontitis and dental caries, (ii) assess interactions between genetic and lifestyle (tobacco and diet) exposures in relation to periodontitis and dental caries, (iii) examine causal relationships between periodontitis and dental caries and cardiometabolic traits (e.g., hyperglycemia, obesity, hypertension, and dyslipidemia) using genotypes as instrumental variables. Around 20,000 observations with GWAS or MetaboChip, and 12,000 Twins all with cardiometabolic traits, lifestyle habits, and dental caries and periodontal status have been pooled from ongoing Swedish studies. GLIDE will then expand by adding cohorts from Finland where a large number of additional GWAS are available. Besides one small study for periodontitis, to date there are no published studies with gene arrays and dental disease risk, which puts the GLIDE study in a unique position.
Principal InvestigatorJohansson, Ingegerd
Coordinating organisation
Umeå University
Funder
Period
2012-01-01 - 2014-12-31
National Category
Public Health, Global Health, Social Medicine and EpidemiologyOther Health Sciences
Identifiers
DiVA, id: project:1124Project, id: 2011-03372_VR