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Title [sv]
Patofysiologi av genotoxinproducerande bakterier vid inflammation och cancer
Title [en]
Pathophysiology of genotoxin producing bacteria in inflammation and cancer
Abstract [en]
An emerging feature in commensal and pathogenic bacteria is the production of genotoxins (BGTX), which are able to induce DNA damage in mammalian cells. The role of these effectors in remodelling the mucosal microenvironment and modulating susceptibility to inflammation and cancer has not been characterized. Using unique models produced in our laboratory, we will address the interplay between bacterial infection and tissue microenvironment, and how this influences the outcome of the bacterial-host interaction. We will investigate:- How BGTX regulates the inflammatory in healthy subjects- How infections with toxigenic bacteria contribute to intestinal inflammation/carcinogenesis- How colonization with BGTX producing bacteria modulates the carcinogenic properties of oncogenic viruses- How the host microbiota modulates BGTX activityOur work aims at understanding whether specific bacterial traits alter the host homeostasis and contribute to the aetiology of inflammatory conditions or cancer, complementing several aspects involved in the regulation of mucosa homeostasis such as: i) specific bacterial products; ii) immune responses; iii) interaction with ubiquitous yet transforming viruses; iv) host microbiota. Understanding whether there is a contribution of BGTX in breaking immunological tolerance and promoting chronic inflammatory diseases and/or tumor development may result in specific and personalized therapeutic interventions and better strategies for disease prevention.
Principal InvestigatorFrisan, Teresa
Coordinating organisation
Umeå University
Funder
Period
2019-01-01 - 2021-12-31
National Category
Cell and Molecular BiologyCancer and OncologyInfectious Medicine
Identifiers
DiVA, id: project:1591Project, id: 2018-02521_VR