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Title [sv]
Virus-glykan interaktioner: betydelse för tropism, behandling och targeting
Title [en]
Virus-glycan interactions: implications for tropism, treatment and targeting
Abstract [en]
Many viruses use cell surface glycans as receptors for attachment to and entry into target cells. Here we will identify sialic acid-containing receptors and characterize their mechanisms of interactions with viral pathogens. This knowledge is of importance to: i) identify determinants that regulate viral tropism, ii) characterize target interactions for antiviral drug development, and iii), improve targeting of vectors to be used for cancer therapy. To address these questions we will study specific members of the Adenoviridae family. These viruses cause disease e.g. in eyes, intestine, and airways, but are also associated with obesity. We will combine advanced MS-based approaches with glycan array technologies for identification of glycan-containing receptors. Their in vitro and in vivo functions will be validated with state-of-the-art attachment and infection methods. Biochemical and structural features of virus-receptor interactions will be studied by surface plasmon resonance and X-ray crystallography. Finally we will develop replication-competent, oncolytic viral vectors re-targeted to glycans that are overexpressed on brain cancer cells, and evaluate specificity and cell-killing capacity in vitro and in vivo. These studies will generate novel insights of the mechanisms that regulate viral tropism and pathogenesis but can also guide antiviral drug development and improve targeting and efficiency of viral vectors used for cancer therapy.
Principal InvestigatorArnberg, Niklas
Coordinating organisation
Umeå University
Funder
Period
2017-12-01 － 2019-12-31
National Category
Microbiology in the medical area
Identifiers
DiVA, id: project:1637Project, id: 2017-00859_VR

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