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Title [sv]
Viral gastroenterit: modeller, molekyler och mekanismer
Title [en]
Viral gastroenteritis: models, molecules, and mechanisms
Abstract [en]
Viral gastroenteritis is a human health problem with more than 500,000 deaths each year but is also a substantial burden to healthcare, and an economic burden to society. Vaccines are available for prevention of rotavirus infection, but antiviral drugs and vaccines are lacking for treatment and prevention of enteric adenovirus (AdV) and norovirus (NoV; the major cause of the infamous winter vomiting disease). The absence of suitable models have prevented in depth studies of the molecular mechanisms whereby the latter viral pathogens cause infection and illness. Our overall aim is to develop models for sustained infection of enteric AdV and NoV, and, to provide novel insights into the molecular mechanisms of infection and illness. We have access to a unique biological toolbox including infectious virus, enteroids, and authentic body fluids from human stomach, gall bladder and pancreas, which together create a near-native environment for enteric AdV and NoV infection. We further use AdV capsid fiber proteins that function as viral enterotoxins, NoV-like particles, and unique cell lines that resemble intestinal, sensory cells that orchestrate rapid onset of nausea, vomiting and diarrhea. We use state-of-the-art technologies such as quantitative proteomics, single cell mRNA sequencing and high-resolution cryo-EM. This project will add knowledge to the area of viral gastroenteritis and will identify novel targets for treatment and prevention.
Principal InvestigatorArnberg, Niklas
Coordinating organisation
Umeå University
Funder
Period
2020-01-01 － 2023-12-31
National Category
Microbiology in the medical area
Identifiers
DiVA, id: project:2089Project, id: 2019-01472_VR

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