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Title [sv]
Cancercellens adaptivt program vid spridning och tillväxt i avlägsna organ och nya terapeutiska strategier
Title [en]
Elucidation of cancer cell adaptive program in initiation of metastatic growth in distant organs and novel therapeutic strategies
Abstract [en]
The final step of cancer metastasis is when the metastatic lesions take over the normal tissue in distant organs, resulting in organ failures. The long term goal of our research is to study the molecular mechanisms underlying metastatic outgrowth of tumors in the distant organs, and to provide new strategies for cancer therapy.  In the proposed study, we will focus on the following specific aims. 1. Identify and characterize gene expression signatures in tumor-initiating cancer cells and in tumor-associated cells from primary tumors and metastatic lesions of prostate and breast cancers. 2. Define the functional impact of cancer cell-specific factors and signaling molecules from tumor-associated cells in initiation of metastatic growth. 3. Explore the therapeutic potentials to target the key players of the metastatic cascades for preventing and treatment of cancer metastasis.For functional and mechanistic analysis, we will focus on the key players of tumor-specific factors including RAS, PIP5K1? and PI3/AKT and their associated network in prostate and breast cancers. We will define the roles of tumor-associated host signals, especially metalloproteinase MMP9 protein. Our established cell line-models, organoid and animal models will be used for testing for targeted drug validation and characterization. Our findings will translate our knowledge into effective treatments for cancer patients with metastatic diseases.
Principal InvestigatorLiao Persson, Jenny
Coordinating organisation
Umeå University
Funder
Period
2020-01-01 － 2022-12-31
National Category
Biomedical Laboratory Science/Technology
Identifiers
DiVA, id: project:2164Project, id: 2019-01318_VR

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