umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Cerebral microbleeds in idiopathic normal pressure hydrocephalus
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Radiation Sciences. Umeå University, Faculty of Science and Technology, Centre for Biomedical Engineering and Physics (CMTF).
Umeå University, Faculty of Medicine, Department of Radiation Sciences.
Umeå University, Faculty of Medicine, Department of Radiation Sciences.
Show others and affiliations
2016 (English)In: Fluids and Barriers of the CNS, ISSN 2045-8118, E-ISSN 2045-8118, Vol. 13, article id 4Article in journal (Refereed) Published
Abstract [en]

Background: A vascular disease could be involved in pathophysiology of normal pressure hydrocephalus (INPH). If so, there should be an association between INPH and cerebral microbleeds (CMB). This study aims to analyze if CMB are associated with INPH.

Methods: In this case-control study we included 14 patients with INPH (mean age 76 years, 60 % female) and 41 healthy controls (HeCo; mean age 71 years, 60 % female). All were investigated with magnetic resonance imaging (MRI) using a T2*-sequence. The MRI exams were reviewed by two neuroradiologists for the presence of CMBs; the prevalence of findings of two or more CMBs was compared between INPH group and control group. After investigation, INPH patients underwent shunt surgery.

Results: Two or more CMB were detected more frequently in the INPH group compared to HeCo (n = 6, 43 % vs. n = 4, 10 %; p = 0.01). Among the participants where MRI revealed CMB, the number of CMB was higher among the INPH patients than the HeCo (median 8; IQR 2-34 vs. median 1; IQR 1-2; p = 0.005).

Conclusions: This study supports a vascular component to the pathophysiology of INPH.

Place, publisher, year, edition, pages
BioMed Central, 2016. Vol. 13, article id 4
Keywords [en]
Idiopathic normal pressure hydrocephalus, Magnetic resonance imaging, Cerebral microbleeds
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-126799DOI: 10.1186/s12987-016-0028-zISI: 000381859400001PubMedID: 26860218OAI: oai:DiVA.org:umu-126799DiVA, id: diva2:1043826
Available from: 2016-11-01 Created: 2016-10-14 Last updated: 2020-03-12Bibliographically approved

Open Access in DiVA

fulltext(804 kB)124 downloads
File information
File name FULLTEXT01.pdfFile size 804 kBChecksum SHA-512
93c3d825d7d023bcff530a510a5aeccc34685e3a32aab1f69b1ea55d0855eee33eb02c2c3911fa2d34299880e6b9ab1c86ca6f380907825f12c3f81d65d4338b
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Johansson, EliasAmbarki, KhalidBirgander, RichardEklund, AndersMalm, Jan

Search in DiVA

By author/editor
Johansson, EliasAmbarki, KhalidBirgander, RichardEklund, AndersMalm, Jan
By organisation
Clinical NeuroscienceDepartment of Radiation SciencesCentre for Biomedical Engineering and Physics (CMTF)
In the same journal
Fluids and Barriers of the CNS
Neurology

Search outside of DiVA

GoogleGoogle Scholar
Total: 124 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 244 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf