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Longitudinal Changes in Component Processes of Working Memory
Umeå University, Faculty of Medicine, Department of Radiation Sciences. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).ORCID iD: 0000-0001-9512-3289
Umeå University, Faculty of Medicine, Department of Radiation Sciences. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).ORCID iD: 0000-0002-3367-1746
2017 (English)In: eNeuro, E-ISSN 2373-2822, Vol. 4, no 2Article in journal (Refereed) Published
Abstract [en]

Working memory (WM) entails maintenance and manipulation of information in the absence of sensory input. This study investigated the trajectories and neural basis of these component processes of WM functions in aging. Longitudinal human functional magnetic resonance imaging (fMRI) data are presented from 136 older individuals (55–80 years) who were scanned at baseline and again 4 years later. We obtained evidence that age-related changes in parietal and frontal components of the WM core network are dissociable in terms of their role in maintenance of perceptual representations and further manipulation of this information, respectively. Individual difference analyses in performance subgroups showed that only prefrontal changes in fMRI activation were accompanied by changes in performance, but parietal brain activity was related to study dropout. We discuss the results in terms of possible neurobiological causes underlying separable aging-related declines in inferior parietal cortex and lateral prefrontal cortex that differentially affect WM functions.

Place, publisher, year, edition, pages
2017. Vol. 4, no 2
National Category
Neurosciences Psychology
Identifiers
URN: urn:nbn:se:umu:diva-132222DOI: 10.1523/ENEURO.0052-17.2017ISI: 000397567900008OAI: oai:DiVA.org:umu-132222DiVA, id: diva2:1078930
Funder
Knut and Alice Wallenberg FoundationRagnar Söderbergs stiftelseAvailable from: 2017-03-07 Created: 2017-03-07 Last updated: 2018-06-09Bibliographically approved

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Rieckmann, AnnaPudas, SaraNyberg, Lars

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Department of Radiation SciencesUmeå Centre for Functional Brain Imaging (UFBI)Department of Integrative Medical Biology (IMB)
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