umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
MicroRNA profile for health risk assessment: environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery
Umeå University, Faculty of Medicine, Department of Biobank Research. Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
Show others and affiliations
2017 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, article id 9262Article in journal (Refereed) Published
Abstract [en]

Persistent organic pollutants (POPs) are synthetic chemical substances that accumulate in our environment. POPs such as polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB) and dichlorodiphenyltrichloroethane (DDT) have been classified as carcinogenic to humans and animals. Due to their resistance to biodegradation humans are still exposed to these compounds worldwide. We aim to evaluate the miRNA and transcriptomic response of a human population exposed to POPs. The miRNA and transcriptomic response was measured in blood of healthy subjects by microarray technology and associated with the serum concentrations of six PCB congeners, DDE (a common DDT metabolite), and HCB. A total of 93 miRNA levels appeared significantly associated with the POP-exposure (FDR < 0.05). The miRNA profile includes four tumor suppressor miRNAs, namely miR-193a-3p, miR-152, miR-31-5p and miR-34a-5p. Integration of the miRNA profile with the transcriptome profile suggests an interaction with oncogenes such as MYC, CCND1, BCL2 and VEGFA. We have shown that exposure to POPs is associated with human miRNA and transcriptomic responses. The identified miRNAs and target genes are related to various types of cancer and involved in relevant signaling pathways like wnt and p53. Therefore, these miRNAs may have great potential to contribute to biomarker-based environmental health risk assessment.

Place, publisher, year, edition, pages
2017. Vol. 7, article id 9262
National Category
Cancer and Oncology Medical Genetics Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:umu:diva-139864DOI: 10.1038/s41598-017-10167-7ISI: 000408435200001PubMedID: 28835693OAI: oai:DiVA.org:umu-139864DiVA, id: diva2:1144063
Available from: 2017-09-25 Created: 2017-09-25 Last updated: 2018-06-09Bibliographically approved

Open Access in DiVA

fulltext(2974 kB)77 downloads
File information
File name FULLTEXT01.pdfFile size 2974 kBChecksum SHA-512
6cec749da404aa3ecea221d0f26ad5b0314504fa39227b0c1a7472647981aee984674ef4552f6ed7744eaad5b67e7894cbcd8ef5ced0bf13ec24a6a7b332f326
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Bergdahl, Ingvar AJohansson, AndersSpaeth, Florentin

Search in DiVA

By author/editor
Bergdahl, Ingvar AJohansson, AndersSpaeth, Florentin
By organisation
Department of Biobank ResearchOccupational and Environmental MedicineNutritional ResearchOncology
In the same journal
Scientific Reports
Cancer and OncologyMedical GeneticsOccupational Health and Environmental Health

Search outside of DiVA

GoogleGoogle Scholar
Total: 77 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 271 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf