Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence
Sahlgrenska Academy at the University of Gothenburg.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology. Sahlgrenska Academy at the University of Gothenburg.
Sahlgrenska Academy at the University of Gothenburg.
Sahlgrenska Academy at the University of Gothenburg.
Show others and affiliations
2011 (English)In: Neuroscience, ISSN 0306-4522, E-ISSN 1873-7544, Vol. 180, p. 201-211Article in journal (Refereed) Published
Abstract [en]

The orexigenic and pro-obesity hormone ghrelin targets key hypothalamic and mesolimbic circuits involved in energy balance, appetite and reward. Given that such circuits are closely integrated with those regulating mood and cognition, we sought to determine whether chronic (>2 weeks) CNS exposure to ghrelin alters anxiety- and depression-like behaviour in rats as well as some physiological correlates. Rats bearing chronically implanted i.c.v. catheters were treated with ghrelin (10 μg/d) or vehicle for 4 weeks. Tests used to assess anxiety- and depression-like behaviour were undertaken during weeks 3-4 of the infusion. These revealed an increase in anxiety- and depression-like behaviour in the ghrelin-treated rats relative to controls. At the end of the 4-week infusion, brains were removed and the amygdala dissected for subsequent qPCR analysis that revealed changes in expression of a number of genes representing key systems implicated in these behavioural changes. Finally, given the key role of the dorsal raphe serotonin system in emotional reactivity, we examined the electrophysiological response of dorsal raphe neurons after a ghrelin challenge, and found mainly inhibitory responses in this region. We demonstrate that the central ghrelin signalling system is involved in emotional reactivity in rats, eliciting pro-anxiety and pro-depression effects and have begun to explore novel target systems for ghrelin that may be of importance for these effects.

Place, publisher, year, edition, pages
Elsevier, 2011. Vol. 180, p. 201-211
Keywords [en]
emotional reactivity, anxiety, depression; memory, GHS-R1A, serotonin
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-82363DOI: 10.1016/j.neuroscience.2011.02.002ISI: 000289395600021PubMedID: 21303683Scopus ID: 2-s2.0-79953196100OAI: oai:DiVA.org:umu-82363DiVA, id: diva2:660966
Funder
Swedish Society for Medical Research (SSMF), VR 2006-5663Swedish Society for Medical Research (SSMF), 2009-S266
Note

Funding was provided by the Swedish Research Council for Medicine (VR 2006-5663; 2009-S266), European Commission 7th Framework (FP7-HEALTH-2009-241592; FP7-KBBE-2009-3-245009), FOUIALF Goteborg (SU7601), Fredrik och Ingrid Thurings Stiftelse, Konrad och Helgfrid Johanssons food and the Swedish Institute and the Swedish Foundation for Strategic Research to Sahlgrenska Center for Cardiovascular and Metabolic Research (A305-188).

Available from: 2013-10-31 Created: 2013-10-31 Last updated: 2023-03-23Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus
By organisation
Physiology
In the same journal
Neuroscience
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 68 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf