umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Antiviral oseltamivir is not removed or degraded in normal sewage water treatment: implications for development of resistance by influenza A virus
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Vise andre og tillknytning
2007 (engelsk)Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 2, nr 10Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Oseltamivir is the main antiviral for treatment and prevention of pandemic influenza. The increase in oseltamivir resistance reported recently has therefore sparked a debate on how to use oseltamivir in non pandemic influenza and the risks associated with wide spread use during a pandemic. Several questions have been asked about the fate of oseltamivir in the sewage treatment plants and in the environment. We have assessed the fate of oseltamivir and discuss the implications of environmental residues of oseltamivir regarding the occurrence of resistance. A series of batch experiments that simulated normal sewage treatment with oseltamivir present was conducted and the UV-spectra of oseltamivir were recorded. Findings: Our experiments show that the active moiety of oseltamivir is not removed in normal sewage water treatments and is not degraded substantially by UV light radiation, and that the active substance is released in waste water leaving the plant. Our conclusion is that a ubiquitous use of oseltamivir may result in selection pressures in the environment that favor development of drug-resistance.

sted, utgiver, år, opplag, sider
Public library of science , 2007. Vol. 2, nr 10
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-16624DOI: 10.1371/journal.pone.0000986OAI: oai:DiVA.org:umu-16624DiVA, id: diva2:156297
Tilgjengelig fra: 2007-10-08 Laget: 2007-10-08 Sist oppdatert: 2018-06-09bibliografisk kontrollert

Open Access i DiVA

fulltext(185 kB)136 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 185 kBChecksum SHA-512
62ae2e781c9904c4c2476728f61ba31cdae6b075a11f88a544a8b4c0a90f386c22fd45b5118cfc5fda1fb33ebab588dfe6600dbe1c0779a39d10c5b4b1c36f08
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fullteksthttp://www.plosone.org/article/fetchArticle.action?articleURI=info:doi/10.1371/journal.pone.0000986

Personposter BETA

Fick, JerkerLindberg, RichardTysklind, MatsOlsen, Björn

Søk i DiVA

Av forfatter/redaktør
Fick, JerkerLindberg, RichardTysklind, MatsOlsen, Björn
Av organisasjonen
I samme tidsskrift
PLoS ONE

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 136 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 262 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf