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Dopamine D2 receptor availability is linked to hippocampal-caudate functional connectivity and episodic memory
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper. Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB). Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI).
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper. Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI).
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB). Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI).
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2016 (engelsk)Inngår i: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 113, nr 28, s. 7918-7923Artikkel i tidsskrift (Fagfellevurdert) Published
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Abstract [en]

D1 and D2 dopamine receptors (D1DRs and D2DRs) may contribute differently to various aspects of memory and cognition. The D1DR system has been linked to functions supported by the prefrontal cortex. By contrast, the role of the D2DR system is less clear, although it has been hypothesized that D2DRs make a specific contribution to hippocampus-based cognitive functions. Here we present results from 181 healthy adults between 64 and 68 y of age who underwent comprehensive assessment of episodic memory, working memory, and processing speed, along with MRI and D2DR assessment with [C-11]raclopride and PET. Caudate D2DR availability was positively associated with episodic memory but not with working memory or speed. Whole-brain analyses further revealed a relation between hippocampal D2DR availability and episodic memory. Hippocampal and caudate D2DR availability were interrelated, and functional MRI-based resting-state functional connectivity between the ventral caudate and medial temporal cortex increased as a function of caudate D2DR availability. Collectively, these findings indicate that D2DRs make a specific contribution to hippocampus-based cognition by influencing striatal and hippocampal regions, and their interactions.

sted, utgiver, år, opplag, sider
2016. Vol. 113, nr 28, s. 7918-7923
Emneord [en]
dopamine, memory, hippocampus
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URN: urn:nbn:se:umu:diva-124327DOI: 10.1073/pnas.1606309113ISI: 000379694100063PubMedID: 27339132OAI: oai:DiVA.org:umu-124327DiVA, id: diva2:1055883
Tilgjengelig fra: 2016-12-13 Laget: 2016-08-04 Sist oppdatert: 2018-06-09bibliografisk kontrollert

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Nyberg, LarsKaralija, NinaAndersson, MicaelWåhlin, AndersAxelsson, JanRieckmann, AnnaRiklund, Katrine

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