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Maintained memory in aging is associated with young epigenetic age
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
Umeå universitet, Samhällsvetenskapliga fakulteten, Enheten för demografi och åldrandeforskning (CEDAR).
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Psykiatri.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
Vise andre og tillknytning
2017 (engelsk)Inngår i: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 55, s. 167-171Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Epigenetic alterations during aging have been proposed to contribute to decline in physical and cognitive functions, and accelerated epigenetic aging has been associated with disease and all-cause mortality later in life. In this study, we estimated epigenetic age dynamics in groups with different memory trajectories (maintained high performance, average decline, and accelerated decline) over a 15-year period. Epigenetic (DNA-methylation [DNAm]) age was assessed, and delta age (DNAm age - chronological age) was calculated in blood samples at baseline (age: 55-65 years) and 15 years later in 52 age- and gender-matched individuals from the Betula study in Sweden. A lower delta DNAm age was observed for those with maintained memory functions compared with those with average (p = 0.035) or accelerated decline (p = 0.037). Moreover, separate analyses revealed that DNAm age at follow-up, but not chronologic age, was a significant predictor of dementia (p = 0.019). Our findings suggest that young epigenetic age contributes to maintained memory in aging.

sted, utgiver, år, opplag, sider
Elsevier, 2017. Vol. 55, s. 167-171
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URN: urn:nbn:se:umu:diva-132221DOI: 10.1016/j.neurobiolaging.2017.02.009ISI: 000405068100018PubMedID: 28292535OAI: oai:DiVA.org:umu-132221DiVA, id: diva2:1078925
Tilgjengelig fra: 2017-03-07 Laget: 2017-03-07 Sist oppdatert: 2019-05-10bibliografisk kontrollert

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Degerman, SofieJosefsson, MariaNordin Adolfsson, AnnelieWennstedt, SigridLandfors, MattiasHaider, ZahraPudas, SaraHultdin, MagnusNyberg, LarsAdolfsson, Rolf

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Degerman, SofieJosefsson, MariaNordin Adolfsson, AnnelieWennstedt, SigridLandfors, MattiasHaider, ZahraPudas, SaraHultdin, MagnusNyberg, LarsAdolfsson, Rolf
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