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Longitudinal Changes in Component Processes of Working Memory
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper. Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI). Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB).
Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI). Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB).ORCID-id: 0000-0001-9512-3289
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper. Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI). Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB).ORCID-id: 0000-0002-3367-1746
2017 (engelsk)Inngår i: eNeuro, E-ISSN 2373-2822, Vol. 4, nr 2Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Working memory (WM) entails maintenance and manipulation of information in the absence of sensory input. This study investigated the trajectories and neural basis of these component processes of WM functions in aging. Longitudinal human functional magnetic resonance imaging (fMRI) data are presented from 136 older individuals (55–80 years) who were scanned at baseline and again 4 years later. We obtained evidence that age-related changes in parietal and frontal components of the WM core network are dissociable in terms of their role in maintenance of perceptual representations and further manipulation of this information, respectively. Individual difference analyses in performance subgroups showed that only prefrontal changes in fMRI activation were accompanied by changes in performance, but parietal brain activity was related to study dropout. We discuss the results in terms of possible neurobiological causes underlying separable aging-related declines in inferior parietal cortex and lateral prefrontal cortex that differentially affect WM functions.

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2017. Vol. 4, nr 2
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-132222DOI: 10.1523/ENEURO.0052-17.2017ISI: 000397567900008OAI: oai:DiVA.org:umu-132222DiVA, id: diva2:1078930
Forskningsfinansiär
Knut and Alice Wallenberg FoundationRagnar Söderbergs stiftelseTilgjengelig fra: 2017-03-07 Laget: 2017-03-07 Sist oppdatert: 2018-06-09bibliografisk kontrollert

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