umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Removal of 30 active pharmaceutical ingredients in surface water under long-term artificial UV irradiation
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Vise andre og tillknytning
2017 (engelsk)Inngår i: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 176, s. 175-182Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

This study investigated the i) kinetics, and ii) proportion of photolysis of 30 relatively stable active pharmaceutical ingredients (APIs) during artificial UV irradiation for 28 d in ammonium acetate buffer, filtered and unfiltered river water. Buffer was included to control removal kinetics under stable pH conditions and without particulate matter. Dark controls were used to determine removal due to other processes than photolysis and calculate the proportion of photolysis of the total removal. The removal of each API in each matrix was determined using online solid phase extraction/liquid chromatography tandem mass spectrometry (online SPE/LC-MS/MS). Most APIs transformed during the 28 d of UV irradiation and the dark controls showed that photolysis was the major removal process for the majority of the APIs studied. The half-lives ranged from 6 h (amitriptyline) in unfiltered river water to 884 h (37 d, carbamazepine) in buffer. In unfiltered river water, the proportion of APIs with short half-lives (<48 h) was much higher (29%) than in the other matrices (4%), probably due to additional organic carbon, which could have promoted indirect photolysis. Furthermore, two APIs, memantine and fluconazole, were stable in all three matrices, while alprazolam was stable in buffer and unfiltered river water and four additional APIs were stable in buffer. Considering the relatively long-term UV-exposure, this study enabled the investigation of environmentally relevant half-lives in natural waters. Many APIs showed high persistence, which is environmentally concerning and emphasizes the importance of further studies on their environmental fate and effects.

sted, utgiver, år, opplag, sider
Elsevier, 2017. Vol. 176, s. 175-182
Emneord [en]
Active pharmaceutical ingredients, Oseltamivir, Photostability, Photolysis, Half-lives, Aquatic environments
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-132650DOI: 10.1016/j.chemosphere.2017.02.063ISI: 000399849300021OAI: oai:DiVA.org:umu-132650DiVA, id: diva2:1082951
Merknad

Corrigendum: Kristin M. Blum, Sara H. Norström, Oksana Golovko, Roman Grabic, Josef D. Järhult, Olga Koba, Hanna Söderström Lindström. Corrigendum to “Removal of 30 active pharmaceutical ingredients in surface water under long-term artificial UV irradiation”. Chemosphere. 2018;208. DOI: 10.1016/j.chemosphere.2018.05.150

Tilgjengelig fra: 2017-03-20 Laget: 2017-03-20 Sist oppdatert: 2018-09-11bibliografisk kontrollert

Open Access i DiVA

fulltext(1590 kB)210 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 1590 kBChecksum SHA-512
6ea5437ddf6fa28ab893b4463e8a7b0272a02e89d6a9e17f0f95d77d2ee06a39c955d7b9a129b17c8203f6d944cefad201ad8003cde310dbdf182000550b536b
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekst

Personposter BETA

Blum, Kristin M.Norström, Sara H.Söderström Lindström, Hanna

Søk i DiVA

Av forfatter/redaktør
Blum, Kristin M.Norström, Sara H.Söderström Lindström, Hanna
Av organisasjonen
I samme tidsskrift
Chemosphere

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 210 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 501 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf