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Epigenetic changes as prognostic predictors in endometrial carcinomas
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Klinisk kemi.ORCID-id: 0000-0001-9673-9982
2017 (engelsk)Inngår i: Epigenetics, ISSN 1559-2294, E-ISSN 1559-2308, Vol. 12, nr 1, s. 19-26Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Endometrial carcinoma is one of the most frequent gynecological malignancies of the female. The diagnostic and prognostic markers for the high-risk subgroups with unfavorable prognosis are under intense debate worldwide, and, therefore, the aim of this study was to identify new potential DNA methylation markers for the high-risk groups. We used the Illumina Infinium HumanMethylation450 BeadChip to analyze the DNA methylation pattern and investigated its association with clinicopathological features important for defining the high-risk (FIGO-grade 3) and low-risk (FIGO-grade 1) groups of patients with endometrial cancer (n = 31 and n = 39, respectively). We identified specific DNA methylation signature in high-risk endometrial tumors, and potential molecular biomarker genes (TBX2, CHST11, and NID2) associated with unfavorable clinical predictive and prognostic factors.

sted, utgiver, år, opplag, sider
2017. Vol. 12, nr 1, s. 19-26
Emneord [en]
DNA methylation, endometrial cancer, FIGO grade, prognosis
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-133259DOI: 10.1080/15592294.2016.1252891ISI: 000394449200003PubMedID: 27874289OAI: oai:DiVA.org:umu-133259DiVA, id: diva2:1088361
Tilgjengelig fra: 2017-04-12 Laget: 2017-04-12 Sist oppdatert: 2018-06-09bibliografisk kontrollert

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