umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Exploring the nature of prediagnostic blood transcriptome markers of chronic lymphocytic leukemia by assessing their overlap with the transcriptome at the clinical stage
Vise andre og tillknytning
2017 (engelsk)Inngår i: BMC Genomics, ISSN 1471-2164, E-ISSN 1471-2164, Vol. 18, artikkel-id 239Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: We recently identified 700 genes whose expression levels were predictive of chronic lymphocytic leukemia (CLL) in a genome-wide gene expression analysis of prediagnostic blood from future cases and matched controls. We hypothesized that a large fraction of these markers were likely related to early disease manifestations. Here we aim to gain a better understanding of the natural history of the identified markers by comparing results from our prediagnostic analysis, the only prediagnostic analysis to date, to results obtained from a meta-analysis of a series of publically available transcriptomics profiles obtained in incident CLL cases and controls.

Results: We observed considerable overlap between the results from our prediagnostic study and the clinical CLL signals (p-value for overlap Bonferroni significant markers 0.01; p-value for overlap nominal significant markers < 2.20e-16). We observed similar patterns with time to diagnosis and similar functional annotations for the markers that were identified in both settings compared to the markers that were only identified in the prediagnostic study. These results suggest that both gene sets operate in similar pathways.

Conclusion: An overlap exists between expression levels of genes predictive of CLL identified in prediagnostic blood and expression levels of genes associated to CLL at the clinical stage. Our analysis provides insight in a set of genes for which expression levels can be used to follow the time-course of the disease; providing an opportunity to study CLL progression in more detail in future studies.

sted, utgiver, år, opplag, sider
2017. Vol. 18, artikkel-id 239
Emneord [en]
B-cell lymphoma, Chronic lymphocytic leukemia, Transcriptomics, Prediagnostic study, Public data
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-133753DOI: 10.1186/s12864-017-3627-4ISI: 000396759800002PubMedID: 28320322OAI: oai:DiVA.org:umu-133753DiVA, id: diva2:1093345
Tilgjengelig fra: 2017-05-05 Laget: 2017-05-05 Sist oppdatert: 2018-06-09bibliografisk kontrollert

Open Access i DiVA

fulltext(2164 kB)72 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 2164 kBChecksum SHA-512
aee01a39525f0307a74b23d87d422f7a1cc84a85a34ce38b3686a460c8082b92e8f7c48929c24611d8aa3b97ed4a758a5e3edcf6b5b2815ed4e2ef965e42a230
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Bergdahl, Ingvar A.Johansson, Ann-Sofie

Søk i DiVA

Av forfatter/redaktør
Bergdahl, Ingvar A.Johansson, Ann-Sofie
Av organisasjonen
I samme tidsskrift
BMC Genomics

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 72 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 261 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf