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Symptoms from masked acrolein exposure suggest altered trigeminal reactivity in chemical intolerance
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.ORCID-id: 0000-0001-5026-4934
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
2017 (engelsk)Inngår i: Neurotoxicology, ISSN 0161-813X, E-ISSN 1872-9711, Vol. 60, s. 92-98Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Chemical intolerance (CI) is a widespread occupational and public health problem characterized by symptoms that reportedly result from low-levels of chemical exposure. The mechanisms behind CI are unknown, however modifications of the chemical senses (rather than toxic processes) have been suggested as key components. The aim of this study was to investigate whether individuals with self-reported CI report more sensory irritation during masked acrolein exposure compared to controls without CI. Methods: Individuals with CI (n = 18) and controls without CI (n = 19) were exposed in an exposure chamber. Each participant took part in two exposure conditions – one with heptane (the masking compound), and one with heptane and acrolein at a dose below previously reported sensory irritation thresholds. The exposures lasted for 60 min. Symptoms and confidence ratings were measured continuously throughout the exposure as were measurements of electrodermal activity and self-reported tear-film break-up time. Participants were blind to exposure condition. Results: Individuals with CI, compared with controls reported greater sensory irritation in the eyes, nose and throat when exposed to acrolein masked with heptane. There was no difference during exposure to heptane. Conclusions: Masked exposure to acrolein at a concentration below the previously reported detection threshold is perceived as more irritating by individuals with CI compared with controls. The results indicate that there is altered trigeminal reactivity in those with CI compared to controls.

sted, utgiver, år, opplag, sider
Elsevier, 2017. Vol. 60, s. 92-98
Emneord [en]
Human exposure, Acrolein, Chemical intolerance, TRPA1, Trigeminal reactivity
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Identifikatorer
URN: urn:nbn:se:umu:diva-136783DOI: 10.1016/j.neuro.2017.03.007ISI: 000403133600010PubMedID: 28359837OAI: oai:DiVA.org:umu-136783DiVA, id: diva2:1113750
Forskningsfinansiär
Swedish Research Council Formas, 2010–1401
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Tilgjengelig fra: 2017-06-22 Laget: 2017-06-22 Sist oppdatert: 2018-06-09bibliografisk kontrollert

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