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Demographic, lifestyle, and other factors in relation to antimullerian hormone levels in mostly late premenopausal women
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2017 (engelsk)Inngår i: Fertility and Sterility, ISSN 0015-0282, E-ISSN 1556-5653, Vol. 107, nr 4Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective: To identify reproductive, lifestyle, hormonal, and other correlates of circulating antimullerian hormone (AMH) concentrations in mostly late premenopausal women. Design: Cross-sectional study. Setting: Not applicable. Patient(s): A total of 671 premenopausal women not known to have cancer. Intervention(s): None. Main Outcome Measure(s): Concentrations of AMH were measured in a single laboratory using the picoAMH ELISA. Multivariable-adjusted median (and interquartile range) AMH concentrations were calculated using quantile regression for several potential correlates. Result(s): Older women had significantly lower AMH concentrations (>= 40 [n = 444] vs. < 35 years [n = 64], multivariable-adjusted median 0.73 ng/mL vs. 2.52 ng/mL). Concentrations of AMH were also significantly lower among women with earlier age at menarche (< 12 [n = 96] vs. >= 14 years [n = 200]: 0.90 ng/mL vs. 1.12 ng/mL) and among current users of oral contraceptives (n = 27) compared with never or former users (n = 468) (0.36 ng/mL vs. 1.15 ng/mL). Race, body mass index, education, height, smoking status, parity, and menstrual cycle phase were not significantly associated with AMH concentrations. There were no significant associations between AMH concentrations and androgen or sex hormone-binding globulin concentrations or with factors related to blood collection (e.g., sample type, time, season, and year of blood collection). Conclusion(s): Among premenopausal women, lower AMH concentrations are associated with older age, a younger age at menarche, and currently using oral contraceptives, suggesting these factors are related to a lower number or decreased secretory activity of ovarian follicles.

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ELSEVIER SCIENCE INC , 2017. Vol. 107, nr 4
Emneord [en]
Antimullerian hormone, demographic, lifestyle, ovarian reserve, reproductive factors
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-136212DOI: 10.1016/j.fertnstert.2017.02.105ISI: 000400459100032PubMedID: 28366409Scopus ID: 2-s2.0-85016464932OAI: oai:DiVA.org:umu-136212DiVA, id: diva2:1117463
Tilgjengelig fra: 2017-06-29 Laget: 2017-06-29 Sist oppdatert: 2023-03-23bibliografisk kontrollert

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