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Inosine triphosphate pyrophosphatase enhances the effect of ribavirin on hepatitis C virus cell culture infection
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk kemi och biofysik.
Vise andre og tillknytning
2017 (engelsk)Inngår i: Journal of Hepatology, ISSN 0168-8278, E-ISSN 1600-0641, Vol. 66, nr 1, s. S321-S321Artikkel i tidsskrift, Meeting abstract (Fagfellevurdert) Published
Abstract [en]

Genetic variants of the inosine triphosphate pyrophosphatase gene (ITPA), resulting in decreased enzymatic activity of the corresponding enzyme, ITPase, are known to correlate with a decreased risk of ribavirin-induced anemia, but are also associated with an increased SVR in patients treated with peginterferon-alpha and ribavirin. As both ITPase and ribavirin are involved in the nucleotide salvage pathway and reduced risk of relapse after treatment of hepatitis C, we have investigated the effect of ITPase activity and ribavirin treatment of HCVcc infection of hepatocytes

sted, utgiver, år, opplag, sider
ELSEVIER SCIENCE BV , 2017. Vol. 66, nr 1, s. S321-S321
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-137018ISI: 000401056600702OAI: oai:DiVA.org:umu-137018DiVA, id: diva2:1117604
Konferanse
International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, APR 19-23, 2017, Amsterdam, NETHERLANDS
Tilgjengelig fra: 2017-06-29 Laget: 2017-06-29 Sist oppdatert: 2018-06-09bibliografisk kontrollert

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Wanrooij, PaulinaChabes, Andrei

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