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Immunohistochemical analysis of EGFR and hyaluronan in tongue cancer and the development of regional recurrence in patients initially diagnosed N0
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Öron- näs- och halssjukdomar.
2017 (engelsk)Inngår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 137, nr 8, s. 877-882Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective: To investigate whether the extent of expression of hyaluronan (HA) and epidermal growth factor receptor (EGFR) in squamous cell carcinoma of the mobile tongue can predict the risk of cervical metastasis and survival.

Study design: Retrospective histopathologic study.

Methods: Surgical specimens from 64 patients who had undergone surgery for squamous cell carcinoma of the mobile tongue were assessed using immunohistochemistry to investigate the expression of HA and EGFR in the primary tumours, and the data were then correlated to cervical metastasis and survival.

Results: There was a significant correlation between the intensity of HA staining and patient survival (p .024), and a weak correlation between the staining proportion of EGFR and the risk for regional recurrence (AUC 66).

Conclusions: This study indicates that immunoscoring using HA could be used to provide prognostic tools for tongue cancer, and that it might be of interest to study the prognostic properties of EGFR further concerning the risk for regional recurrence after the primary treatment.

sted, utgiver, år, opplag, sider
Taylor & Francis, 2017. Vol. 137, nr 8, s. 877-882
Emneord [en]
Epidermal growth factor receptor expression, immunoscoring, oral tongue squamous cell carcinoma, prognostic factors, biomarkers
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-137891DOI: 10.1080/00016489.2017.1292049ISI: 000404684100016PubMedID: 28355940OAI: oai:DiVA.org:umu-137891DiVA, id: diva2:1129907
Tilgjengelig fra: 2017-08-07 Laget: 2017-08-07 Sist oppdatert: 2019-05-10bibliografisk kontrollert

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