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The complete genome sequence of human adenovirus 84, a highly recombinant new Human mastadenovirus D type with a unique fiber gene
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi. Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary. (Niklas Arnberg)ORCID-id: 0000-0001-8213-8238
Vise andre og tillknytning
2017 (engelsk)Inngår i: Virus Research, ISSN 0168-1702, E-ISSN 1872-7492, Vol. 242, s. 79-84Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

A novel human adenovirus was isolated from a pediatric case of acute respiratory disease in Panama City, Panama in 2011. The clinical isolate was initially identified as an intertypic recombinant based on hexon and fiber gene sequencing. Based on the analysis of its complete genome sequence, the novel complex recombinant Human mastadenovirus D (HAdV-D) strain was classified into a new HAdV type: HAdV-84, and it was designated Adenovirus D human/PAN/P309886/2011/84[P43H17F84]. HAdV-D types possess usually an ocular or gastrointestinal tropism, and respiratory association is scarcely reported. The virus has a novel fiber type, most closely related to, but still clearly distant from that of HAdV-36. The predicted fiber is hypothesised to bind sialic acid with lower affinity compared to HAdV-37. Bioinformatic analysis of the complete genomic sequence of HAdV-84 revealed multiple homologous recombination events and provided deeper insight into HAdV evolution.

sted, utgiver, år, opplag, sider
Elsevier, 2017. Vol. 242, s. 79-84
Emneord [en]
Human adenovirus, Complete genome, HAdV-84, Homologous recombination, HAdV-D, Acute respiratory disease
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-142911DOI: 10.1016/j.virusres.2017.09.012ISI: 000415777800011PubMedID: 28923509OAI: oai:DiVA.org:umu-142911DiVA, id: diva2:1165529
Tilgjengelig fra: 2017-12-13 Laget: 2017-12-13 Sist oppdatert: 2018-06-09bibliografisk kontrollert

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Kaján, Gyõzõ L.Arnberg, Niklas

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