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Cord blood eicosanoid signatures and newborn gestational age
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Department of Entomology and Nematology, University of California, Davis, CA, USA.
2017 (engelsk)Inngår i: Prostaglandins & other lipid mediators, ISSN 1098-8823, E-ISSN 2212-196X, Vol. 133, s. 123-127Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Beyond prostaglandins, the function of eicosanoids and other oxylipins in pregnancy and labor is poorly understood. In contrast to earlier work focusing on preterm infants, we investigated how oxylipin levels in newborns (measured in cord blood) vary during the last weeks of pregnancy in 190 mother-newborns (≥37 weeks of gestation) of the ENVIRONAGE birth cohort, Belgium. We found increased levels of PGE2 (p = 0.003), PGF (p = 0.042), 8,9-DHET (p = 0.037), 11-HETE (p = 0.034), and 15-HETrE (p = 0.008) associated with full term pregnancy compared to early term labor. Furthermore, late vs early term was associated with increased levels of PGE2 (p = 0.012) and TXB2 (p = 0.033), while late vs full term was associated with decreased levels of 14,15-DHET (p = 0.029), 11,12-DHET (p = 0.033), and 5-HETE (p = 0.045). To summarize, nine eicosanoids, derived via three enzymatic pathways, were significantly associated with gestational age. Eight of these were derived from arachidonic acid, and one from dihomo-γ-linolenic acid.

sted, utgiver, år, opplag, sider
Elsevier, 2017. Vol. 133, s. 123-127
Emneord [en]
Eicosanoids, Gestational age, Lipid metabolism, Mass spectrometry
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-143948DOI: 10.1016/j.prostaglandins.2017.07.003ISI: 000418729100017PubMedID: 28736329OAI: oai:DiVA.org:umu-143948DiVA, id: diva2:1174208
Konferanse
6th European Workshop on Lipid Mediators (EWLM), SEP 27-30, 2016, Goethe Univ, Frankfurt, GERMANY
Tilgjengelig fra: 2018-01-15 Laget: 2018-01-15 Sist oppdatert: 2018-06-09bibliografisk kontrollert

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