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Muscle changes in patients with diabetes and chronic exertional compartment syndrome before and after treatment with fasciotomy
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap.
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap.
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB).
2018 (engelsk)Inngår i: Muscle and Nerve, ISSN 0148-639X, E-ISSN 1097-4598, Vol. 57, nr 2, s. 229-239Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Introduction: Muscle changes in patients with diabetes and lower leg pain due to chronic exertional compartment syndrome (CECS) were investigated before and after fasciotomy. Methods: The tibialis anterior muscle was analyzed with histochemical and morphological techniques in 7 patients with diabetes and CECS before fasciotomy and in 5 of them 1 year after fasciotomy. Nondiabetic patients with CECS and healthy participants served as references. Results: Before treatment, walking distance until occurrence of pain was limited (<0.2 km). Intramuscular pressure was significantly higher than in reference participants. Muscle analysis showed changes pathognomonic for neuropathy and myopathy and a restricted capillary network, with significantly more severe changes in the muscles of patients with diabetes than in the muscles of nondiabetic patients. Treatment with fasciotomy improved clinical signs, increased walking ability, and reduced muscle abnormalities, but muscle capillarization remained low. Discussion: Patients with diabetes and CECS have distinct pathological changes in affected muscles. Pressure-relieving fasciotomy triggers a regenerative response in the muscle tissue but not in the capillary bed.

sted, utgiver, år, opplag, sider
WILEY , 2018. Vol. 57, nr 2, s. 229-239
Emneord [en]
angiopathy, capillaries, compartment syndrome, diabetes, fasciotomy, muscle, myopathy, uropathy
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-144342DOI: 10.1002/mus.25715ISI: 000419964700016PubMedID: 28561900OAI: oai:DiVA.org:umu-144342DiVA, id: diva2:1181092
Tilgjengelig fra: 2018-02-07 Laget: 2018-02-07 Sist oppdatert: 2019-05-17bibliografisk kontrollert

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