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Neurocognitive Profiles of Older Adults with Working-Memory Dysfunction
Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI). Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Diagnostisk radiologi. Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI).
Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI). Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Diagnostisk radiologi.
Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI). Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
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2018 (engelsk)Inngår i: Cerebral Cortex, ISSN 1047-3211, E-ISSN 1460-2199, Vol. 28, nr 7, s. 2525-2539Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Individuals differ in how they perceive, remember, and think. There is evidence for the existence of distinct subgroups that differ in cognitive performance within the older population. However, it is less clear how individual differences in cognition in old age are linked to differences in brain-based measures. We used latent-profile analysis on n-back working-memory (WM) performance to identify subgroups in a large sample of older adults (n = 181; age = 64-68 years). Our analysis identified one larger normal subgroup with higher performance (n = 113; 63%), and a second smaller subgroup (n = 55; 31%) with lower performance. The low-performing subgroup showed weaker load-dependent BOLD modulation and lower connectivity within the fronto-parietal network (FPN) as well as between FPN and striatum during n-back, along with lower FPN connectivity at rest. This group also exhibited lower FPN structural integrity, lower frontal dopamine D2 binding potential, inferior performance on offline WM tests, and a trend-level genetic predisposition for lower dopamine-system efficiency. By contrast, this group exhibited relatively intact episodic memory and associated brain measures (i.e., hippocampal volume, structural, and functional connectivity within the default-mode network). Collectively, these data provide converging evidence for the existence of a group of older adults with impaired WM functioning characterized by reduced cortico-striatal coupling and aberrant cortico-cortical integrity within FPN.

sted, utgiver, år, opplag, sider
Oxford University Press, 2018. Vol. 28, nr 7, s. 2525-2539
Emneord [en]
dopamine, fronto-parietal network, functional connectivity, individual differences, working memory
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-150747DOI: 10.1093/cercor/bhy062ISI: 000437165800025PubMedID: 29901790OAI: oai:DiVA.org:umu-150747DiVA, id: diva2:1239504
Tilgjengelig fra: 2018-08-16 Laget: 2018-08-16 Sist oppdatert: 2018-08-16bibliografisk kontrollert

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Salami, AlirezaRieckmann, AnnaKaralija, NinaAndersson, MicaelWåhlin, AndersRiklund, KatrineNyberg, Lars

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