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An attenuated replication-competent chikungunya virus with a fluorescently tagged envelope
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2018 (engelsk)Inngår i: PLoS Neglected Tropical Diseases, ISSN 1935-2727, E-ISSN 1935-2735, Vol. 12, nr 7, artikkel-id e0006693Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Chikungunya virus (CHIKV) is the most common alphavirus infecting humans worldwide, causing acute and chronically debilitating arthralgia at a great economic expense.

Methodology/Principal findings: To facilitate our study of CHIKV, we generated a mCherry tagged replication-competent chimeric virus, CHIKV 37997-mCherry. Single particle cryoEM demonstrated icosahedral organization of the chimeric virus and the display of mCherry proteins on virus surface. CHIKV 37997-mCherry is attenuated in both IFN alpha R knockout and wild-type mice. Strong antiCHIKV and anti-mCherry antibody responses were induced in CHIKV 37997-mCherry infected mice.

Conclusions/Significance: Our work suggests that chimeric alphaviruses displaying foreign antigen can serve as vaccines against both aphaviruses and other pathogens and diseases.

sted, utgiver, år, opplag, sider
PUBLIC LIBRARY SCIENCE , 2018. Vol. 12, nr 7, artikkel-id e0006693
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-150733DOI: 10.1371/journal.pntd.0006693ISI: 000440495700064PubMedID: 30063703Scopus ID: 2-s2.0-85051301762OAI: oai:DiVA.org:umu-150733DiVA, id: diva2:1242265
Tilgjengelig fra: 2018-08-27 Laget: 2018-08-27 Sist oppdatert: 2018-08-27bibliografisk kontrollert

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