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Intracranial and Intraocular Pressure at the Lamina Cribrosa: Gradient Effects
Umeå universitet, Medicinska fakulteten, Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM). Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Oftalmiatrik.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Oftalmiatrik.
2018 (engelsk)Inngår i: Current Neurology and Neuroscience Reports, ISSN 1528-4042, E-ISSN 1534-6293, Vol. 18, nr 5, artikkel-id 25Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Purpose of Review A pressure difference between the intraocular and intracranial compartments at the site of the lamina cribrosa has been hypothesized to have a pathophysiological role in several optic nerve head diseases. This paper reviews the current literature on the translamina cribrosa pressure difference (TLCPD), the associated pressure gradient, and its potential pathophysiological role, as well as the methodology to assess TLCPD. Recent Findings For normal-tension glaucoma (NTG), initial studies indicated low intracranial pressure (ICP) while recent findings indicate that a reduced ICP is not mandatory. Summary Data from studies on the elevated TLCPD as a pathophysiological factor of NTG are equivocal. From the identification of potential postural effects on the cerebrospinal fluid (CSF) communication between the intracranial and retrolaminar space, we hypothesize that the missing link could be a dysfunction of an occlusion mechanism of the optic nerve sheath around the optic nerve. In upright posture, this could cause an elevated TLCPD even with normal ICP and we suggest that this should be investigated as a pathophysiological component in NTG patients.

sted, utgiver, år, opplag, sider
SPRINGER , 2018. Vol. 18, nr 5, artikkel-id 25
Emneord [en]
Translamina cribrosa pressure difference, Translaminar pressure difference, Cerebrospinal fluid, Intracranial pressure, Intraocular pressure, Normal tension
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Identifikatorer
URN: urn:nbn:se:umu:diva-150706DOI: 10.1007/s11910-018-0831-9ISI: 000430797500004PubMedID: 29651628Scopus ID: 2-s2.0-85045399299OAI: oai:DiVA.org:umu-150706DiVA, id: diva2:1244812
Tilgjengelig fra: 2018-09-03 Laget: 2018-09-03 Sist oppdatert: 2018-09-03bibliografisk kontrollert

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