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Prevention and treatment of type 2 diabetes is of paramount importance as this metabolic disease is associated to life-threatening complications and diseases implicated in premature death. The aim of this study was to investigate metabolic adaptations to exercise-training in overweight young females and males. The intervention consisted of 7 weeks of moderate to high intensity aerobic-training combined with resistance-training, without calorie restrictions, including pre and post-tests. The major result was a significant increase in adiponectin by an average of 27% (95% CI [0.10, 0.84], p=0.006, d=0.65) and a significant decrease in the late phase (30-60 min) insulin response to an oral macronutrient load by an average of 16% (95% CI [-68, -8], p=0.009, d=-0.66), despite no change in body weight. Tests of correlations indicated that improvements in metabolic health were associated to participating in the study, rather than to improvements in body composition and/or cardiorespiratory fitness. Females received major improvements in metabolic health compare to the males. However, a heterogeneous degree of metabolic adaptation to the intervention made it difficult to draw any definitive conclusions. Conclusively, it seem that a 7 week period of exercise-training can improve metabolic health assessed by adiponectin and insulin response in overweight young adults.