umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Performance of the Expanded Cardiovascular Risk Prediction Score for Rheumatoid Arthritis in a geographically distant National Register-based cohort: an external validation
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Reumatologi. Department of Medicine Solna, Clinical Epidemiology Section, Karolinska Institutet, Stockholm, Sweden.
Vise andre og tillknytning
2018 (engelsk)Inngår i: RMD Open, E-ISSN 2056-5933, Vol. 4, nr 2, artikkel-id UNSP e000771Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background Cardiovascular (CV) risk stratification for patients with rheumatoid arthritis (RA) should facilitate evidence-based management. Prior work has derived an internally validated a CV risk score, the Expanded Cardiovascular Risk Prediction Score for Rheumatoid Arthritis (ERS-RA), using US data. The aim of this study was to perform an external validation among unselected patients with RA from Europe. Methods Three large, partially overlapping, cohorts of patients with RA from the Swedish Rheumatology Quality register were identified for external validation, two with information on smoking and two with close to 10 years of median follow-up. The 10-year rate of first CV events was assessed using the Kaplan-Meier method. The performance of ERS-RA was assessed using C-index and comparisons of observed versus predicted risks. Results The C-index for ERS-RA varied across the three RA cohorts, from 0.75 to 0.78. Predicted risks corresponded well to observed risks among individuals with <= 10 % observed 10-year CV risk, but underestimated risk in individuals with a higher observed risk. In the absence of data on smoking, ERS-RA underestimated the CV risk by 3.3%, whereas in the cohorts including data on smoking, the calibration was within 1% (0.06% and 0.7%). In the clinically relevant risk intervals (<5%, 5.0%-<7.5%, 7.5%-<10%), ERS-RA performed well. Conclusions In an unselected Swedish population with RA, ERS-RA performed well, although the 10-year CV risk was underestimated in high-risk groups and in the absence of data on smoking. ERS-RA could be considered as a risk stratification tool for targeted preventive interventions in clinical rheumatology practice.

sted, utgiver, år, opplag, sider
BMJ Publishing Group Ltd, 2018. Vol. 4, nr 2, artikkel-id UNSP e000771
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-156014DOI: 10.1136/rmdopen-2018-000771ISI: 000455537200028PubMedID: 30622736OAI: oai:DiVA.org:umu-156014DiVA, id: diva2:1284662
Forskningsfinansiär
Västerbotten County CouncilSwedish Rheumatism AssociationNIH (National Institute of Health), R01 HL127118Tilgjengelig fra: 2019-02-01 Laget: 2019-02-01 Sist oppdatert: 2019-02-01bibliografisk kontrollert

Open Access i DiVA

fulltext(1104 kB)43 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 1104 kBChecksum SHA-512
1a645da5486e824a250e7f3180c7ee279b87f6ab7763931df9f99bb9e03eee77ce90c65fe3e13b52545779b6be5de0154650a943421e4f7c759157e7d1de94bd
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Ljung, Lotta

Søk i DiVA

Av forfatter/redaktør
Ljung, Lotta
Av organisasjonen
I samme tidsskrift
RMD Open

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 43 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 71 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf