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Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin. Department of Nephrology, Skaraborgs Hospital, Skövde.ORCID-id: 0000-0002-5872-0583
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2019 (engelsk)Inngår i: Artificial Organs, ISSN 0160-564X, E-ISSN 1525-1594, Vol. 43, nr 2, s. 173-180Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Tissue advanced glycation end products (AGEs) are a measure of cumulative metabolic and oxidative stress and cytokine-driven inflammatory reactions. AGEs are thought to contribute to the cardiovascular complications of hemodialysis (HD) patients. Skin autofluorescence (SAF) is related to the tissue accumulation of AGEs and rises with age. SAF is one of the strongest prognostic markers of mortality in these patients. The content of AGEs is high in barbecue food. Due to the location in northern Sweden, there is a short intense barbecue season between June and August. The aim of this study was to investigate if seasonal variations in SAF exist in HD patients, especially during the barbecue season. SAF was measured noninvasively with an AGE Reader in 34 HD-patients (15 of those with diabetes mellitus, DM). Each time the median of three measures were used. Skin-AF was measured before and after each one HD at the end of February and May in 31 patients (22 men/9 women); the end of May and August in 28 (20 m/8 w); the end of August and March in 25 (19 m/6 w). Paired statistical analyses were performed during all four periods (n = 23, 17 m/6 w); as was HbA1c of those with DM. There was at a median 5.6% increase in skin-AF during the winter period (February-May, P = 0.004) and a 10.6% decrease in the skin-AF during the summer (May-August, P < 0.001). HbA1c in the DM rose during the summer (P = 0.013). In conclusion, skin-AF decreased significantly during the summer. Future studies should look for favorable factors that prevent skin-AF and subsequently cardiovascular diseases.

sted, utgiver, år, opplag, sider
Wiley Periodicals, Inc. , 2019. Vol. 43, nr 2, s. 173-180
Emneord [en]
Skin autofluorescence, Hemodialysis, Seasonal variations, Advanced glycation end products
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-157223DOI: 10.1111/aor.13320ISI: 000459167900010PubMedID: 30229953OAI: oai:DiVA.org:umu-157223DiVA, id: diva2:1298276
Tilgjengelig fra: 2019-03-22 Laget: 2019-03-22 Sist oppdatert: 2019-03-22bibliografisk kontrollert

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