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The prevalence of prolonged QTc increases by GOLD stage, and is associated with worse survival among subjects with COPD
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för medicin.ORCID-id: 0000-0002-2574-479x
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för medicin.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för medicin.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för medicin.
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2019 (engelsk)Inngår i: Heart & Lung, ISSN 0147-9563, E-ISSN 1527-3288, Vol. 48, nr 2, s. 148-154Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: The role of QTc-prolongation, in relation to the increased mortality in COPD, is unclear.

Objectives: To estimate the prevalence and prognostic impact, assessed as mortality, of QTc-prolongation in COPD, restrictive spirometric pattern (RSP), and normal lung function (NLF), respectively.

Methods: All individuals (n = 993) with COPD and age- and sex-matched non-obstructive referents were identified from well-defined population-based cohorts examined in Northern Sweden in 2002–04. In 2005, the study-sample was invited to re-examination including ECG; QTc was calculated and mortality data collected until 31st December 2010.

Results: The prevalence of QTc-prolongation was higher among people with RSP than among those with NLF and, although similar in NLF and COPD, the prevalence increased by COPD-severity. Among participants with COPD, those with QTc prolongation had higher mortality than those with normal QTc, while no such differences were found among participants with NLF or RSP.

Conclusion: Among participants with COPD, the prevalence of QTc-prolongation increased by disease-severity and was associated with mortality.

sted, utgiver, år, opplag, sider
Elsevier, 2019. Vol. 48, nr 2, s. 148-154
Emneord [en]
Epidemiology, Comorbidity, Cardiology, Electrocardiogram, Pulmonary disease, Chronic obstructive
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Identifikatorer
URN: urn:nbn:se:umu:diva-158114DOI: 10.1016/j.hrtlng.2018.09.015ISI: 000462808300013PubMedID: 30391074OAI: oai:DiVA.org:umu-158114DiVA, id: diva2:1304478
Forskningsfinansiär
Swedish Heart Lung FoundationTilgjengelig fra: 2019-04-12 Laget: 2019-04-12 Sist oppdatert: 2019-04-12bibliografisk kontrollert

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Nilsson, UlfDiamant, Ulla-BrittBlomberg, AndersLindberg, Anne

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