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Preliminary exploration of hsa_circ_0032131 levels in peripheral blood as a potential diagnostic biomarker of osteoarthritis
Department of Orthopedics, the First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China.
School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an, People's Republic of China.
Department of Orthopedics, the First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China.
Department of Orthopedics, the First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China.
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2019 (engelsk)Inngår i: Genetic Testing and Molecular Biomarkers, ISSN 1945-0265, E-ISSN 1945-0257, Vol. 23, nr 10, s. 717-721Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Osteoarthritis (OA) is a common chronic degenerative joint disease characterized by articular cartilage degeneration and synovitis. CircRNAs are increasingly being recognized as functional endogenous RNAs with a stable structure and high tissue specificity. Recent studies have shown that some circRNAs may be involved in the initiation and progression of OA and that there is differential expression of circRNAs in chondrocytes in vitro isolated from patients with OA.

Purposes: In this study, we aimed to determine if circRNA levels in the peripheral blood of Chinese Han patients with OA would be diagnostic based on the previous in vitro studies.

Methods: We collected peripheral blood samples from 25 patients suffering from OA and 25 healthy controls and measured hsa_circ_0032131_CBC1 RNA levels through quantitative RT-PCR (qRT-PCR). The statistical basis for evaluating the diagnostic value was to calculate the area under the receiver operator characteristic (ROC) curve.

Results: The results of the qRT-PCR for hsa_circ_0032131_CBC1 were consistent with those of the microarray analysis. The ROC curve shows that hsa_circ_0032131 holds diagnostic value for OA (0.8455, p < 0.01).

Conclusions: Our research indicates that differentially expressed circRNAs may be involved in the development of OA and could be used diagnostically.

sted, utgiver, år, opplag, sider
Mary Ann Liebert, 2019. Vol. 23, nr 10, s. 717-721
Emneord [en]
circRNA, diagnostic biomarker, osteoarthritis, peripheral blood
HSV kategori
Forskningsprogram
molekylärbiologi; ortopedi; reumatologi; medicinsk biokemi
Identifikatorer
URN: urn:nbn:se:umu:diva-163634DOI: 10.1089/gtmb.2019.0036ISI: 000486800600001PubMedID: 31526191OAI: oai:DiVA.org:umu-163634DiVA, id: diva2:1356146
Tilgjengelig fra: 2019-10-01 Laget: 2019-10-01 Sist oppdatert: 2019-11-11bibliografisk kontrollert

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