umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Platelet-stored antibodies potently diminish viral infection in vitro and in vivo
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi. Institute for Vascular Biology and Thrombosis Research, Medical University of Vienna, Austria.
Vise andre og tillknytning
2019 (engelsk)Inngår i: Acta Physiologica, ISSN 1748-1708, E-ISSN 1748-1716, Vol. 227, nr S718, s. 187-187Artikkel i tidsskrift, Meeting abstract (Annet vitenskapelig) Published
Abstract [en]

Besides their primary role in haemostasis, platelets are actively involved in immune responses as they respond to various inflammatory stimuli, including microbial infection. Further, platelets contain intracellular IgG, but their physiologic function remains unknown. Thus, we aimed to elucidate the function of platelet-derived IgGs and their effect on viral infections. Human and murine platelets contained IgG which were released upon shear stress. However, IgG loss did not correlate with P-Selectin exposure or CXCL4 release and α-granule deficient (Nbeal2-/-) platelets failed to show reduced IgG content and release, indicating an extragranular IgG storage site within platelets. While platelet IgG could derive from megakaryocytes that have taken up IgG from the bone marrow microenvironment, naïve platelets also took up IgG directly from plasma in vitro and in vivo. Murine platelets from anti-IAV IgG seropositive mice reduced IAV infection in vitro and in vivo more efficiently than plasma containing comparable IgG levels. Further, human platelets from anti-CMV IgG seropositive but not seronegative donors also potently neutralized in vitro CMV-infection of HUVEC under microvascular shear stress. Our data indicate that IgG storage in platelets may not be restricted to α-granules. Further, our results show that platelets have the potential to mediate potent IgG-mediated antiviral effects both in vitro and in vivo directly at foci of infection. This indicates that platelet-derived IgG may represent a yet unexplored mechanism for focused serological immunity.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2019. Vol. 227, nr S718, s. 187-187
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-164632DOI: 10.1111/apha.13366ISI: 000485252000449OAI: oai:DiVA.org:umu-164632DiVA, id: diva2:1370273
Konferanse
Joint Meeting of the Federation of European Physiological Societies (FEPS) and the Italian Physiological Society (SIF), Bologna (Italy), 10–13 September, 2019
Tilgjengelig fra: 2019-11-14 Laget: 2019-11-14 Sist oppdatert: 2019-11-14bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekst

Personposter BETA

Schrottmaier, Waltraud C.Forsell, Mattias

Søk i DiVA

Av forfatter/redaktør
Schrottmaier, Waltraud C.Forsell, Mattias
Av organisasjonen
I samme tidsskrift
Acta Physiologica

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 31 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf