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Characterization of healthy skin using near infrared spectroscopy and skin impedance
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Centrum för medicinsk teknik och fysik (CMTF).
2008 (engelsk)Inngår i: Medical and Biological Engineering and Computing, ISSN 0140-0118, E-ISSN 1741-0444, Vol. 46, nr 10, s. 985-995Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Near infrared spectroscopy (NIR) and skin impedance (IMP) spectroscopy are two methods suggested for diagnoses of diseases inducing adverse effects in skin. The reproducibility of these methods and their potential value in non-invasive diagnostics were investigated. Measurements were performed in vivo on healthy skin at five anatomic body sites on eight young women. partial least squares discriminant analysis showed that both methods were useful for classification of the skin characteristics at the sites. Inter-individually the NIR model gave 100% correct classification while the IMP model provided 92%. Intra-individually the NIR model gave 88% correct classification whereas the IMP model did not provide any useful classification. The correct classification was increased to 93% when both datasets were combined, which demonstrates the value of adding information. Partial least squares discriminant analysis gave 72% correct predictions of skin sites while the combined model slightly improved to 73%.

sted, utgiver, år, opplag, sider
2008. Vol. 46, nr 10, s. 985-995
Emneord [en]
Near infrared diffuse reflectance spectroscopy, Skin impedance, Multivariate data analysis, Skin characterization, Reproducibility
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-9958DOI: 10.1007/s11517-008-0343-xPubMedID: 18478287OAI: oai:DiVA.org:umu-9958DiVA, id: diva2:149629
Tilgjengelig fra: 2008-11-18 Laget: 2008-11-18 Sist oppdatert: 2018-06-09bibliografisk kontrollert
Inngår i avhandling
1. Near infrared and skin impedance spectroscopic in vivo measurements on human skin: development of a diagnostic tool for skin cancer
Åpne denne publikasjonen i ny fane eller vindu >>Near infrared and skin impedance spectroscopic in vivo measurements on human skin: development of a diagnostic tool for skin cancer
2011 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Every year approximately 2800 Swedes are diagnosed with malignant melanoma, the form of cancer that is most rapidly increasing in incidence in the Western world. The earlier we can identify and diagnose a malignant melanoma, the better is the prognosis. In Sweden, 155 000 benign naevi, harmless skin tumours or moles, are surgically excised each year, many of them because melanoma cannot be dismissed by non-invasive methods. The excisions result in substantial medical costs and cause unrest and suffering of the individual patient. For untrained physicians, it is often difficult to make an accurate diagnosis of melanoma, thus a tool that could help to strengthen the diagnosis of suspected melanomas would be highly valuable. This thesis describes the development and assessment of a non-invasive method for early skin cancer detection. Using near infrared (NIR) and skin impedance spectroscopy, healthy and diseased skin of various subjects was examined to develop a new instrument for detecting malignant melanoma. Due to the complex nature of skin and the numerous variables involved, the spectroscopic data were analysed multivariately using Principal Component Analysis (PCA) and partial leas square discriminant analysis (PLS-DA). The reproducibility of the measurements was determined by calculating Scatter Values (SVs), and the significance of separations between overlapping groups in score plots was determined by calculating intra-model distances.

The studies indicate that combining skin impedance and NIR spectroscopy measurements adds value, therefore a new probe-head for simultaneous NIR and skin impedance measurements was introduced. Using both spectroscopic techniques it was possible to separate healthy skin at one body location from healthy skin at another location due to the differences in skin characteristics at various body locations. In addition, statistically significant differences between overlapping groups of both age and gender in score plots were detected. However, the differences in skin characteristics at different body locations had stronger effects on the measurements than both age and gender. Intake of coffee and alcohol prior to measurement did not significantly influence the outcome data. Measurements on dysplastic naevi were significantly separated in a score plot and the influence of diseased skin was stronger than that of body location. This was confirmed in a study where measurements were performed on 12 malignant melanomas, 19 dysplastic naevi and 19 benign naevi. The malignant melanomas were significantly separated from both dysplastic naevi and benign naevi.

Overall, the presented findings show that the instrument we have developed provides fast, reproducible measurements, capable of distinguishing malignant melanoma from dysplastic naevi and benign naevi non-invasively with 83% sensitivity and 95% specificity. Thus, the results are highly promising and the instrument appears to have high potential diagnostic utility.

sted, utgiver, år, opplag, sider
Umeå: Umeå universitet, 2011. s. 51
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 1466
Emneord
Combined probe head, Malignant melanoma, diagnosis, NIR, Skin impedance, PCA, PLS-DA
HSV kategori
Forskningsprogram
kirurgi
Identifikatorer
urn:nbn:se:umu:diva-50605 (URN)978-91-7459-335-8 (ISBN)
Disputas
2012-01-27, KB3A9, KBC, Umeå universitet, Umeå, 10:00 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2011-12-23 Laget: 2011-12-15 Sist oppdatert: 2018-06-08bibliografisk kontrollert

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