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Differences in expression of tumor markers between pre- and postmenopausal women with invasive cervical cancer.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
2008 (engelsk)Inngår i: Anticancer Res, ISSN 0250-7005, Vol. 28, nr 3B, s. 1793-1795Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

THE AIM of the present study was to investigate the differences in the expression of tumor markers in squamous cell and in adenomatous carcinomas in pre- and postmenopausal women, respectively.

PATIENTS AND METHODS:

The study population comprised 53 premenopausal and 107 postmenopausal women. Thirty-four tumors were adenomatous (n=31) or adenosquamous carcinomas (n=3), distributed between 13 premenopausal and 21 postmenopausal women. The remaining 126 squamous cell carcinomas were diagnosed in 40 pre- and 86 postmenopausal women. Expression of ten tumor markers of possible clinical importance in cervical cancer was evaluated.

RESULTS:

Expression of three tumor markers, p53 (>0% vs. 0%), p27 (> or =20% vs. <20%) and cyclooxygenase-2 (COX-2) (high intensity vs. moderate/none) differed significantly between pre- compared to postmenopausal women with squamous cell (p27; 54% vs. 72%, p=0.009) or adenomatous carcinomas (p53; 8% vs. 63%, p=0.006 and COX-2; 46% vs. 20%, p=0.03). All results were adjusted for clinical cancer stage.

CONCLUSION:

The unusual age-specific incidence curve in cervical cancer has rarely been related to expression of tumor markers. Age-related differences in expression of tumor markers could reflect some age-related different biological mechanisms in cervical cancer.

sted, utgiver, år, opplag, sider
2008. Vol. 28, nr 3B, s. 1793-1795
Emneord [en]
Cervical cancer, markers, p53, p27, COX-2, Ki-67, EGFR, E-cadherin, c-myc, VEGF, CD44, CD4, age-specific expression
Identifikatorer
URN: urn:nbn:se:umu:diva-10410PubMedID: 18630462OAI: oai:DiVA.org:umu-10410DiVA, id: diva2:150081
Tilgjengelig fra: 2008-09-05 Laget: 2008-09-05 Sist oppdatert: 2011-08-25bibliografisk kontrollert

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