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The molecular composition of the sarcomeric M-band correlates with muscle fiber type
ETH-Zurich Hoenggerberg.
ETH-Zurich Hoenggerberg.
King×s College London,.
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB), Anatomi.
Vise andre og tillknytning
2004 (engelsk)Inngår i: European Journal of Cell Biology, ISSN 0171-9335, Vol. 83, nr 5, s. 193-204Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The M-band is the transverse structure that cross-links the thick filaments in the center and provides a perfect alignment of the A-band in the activated sarcomere. The molecular composition of the M-bands in adult mouse skeletal muscle is fiber-type dependent. All M-bands in fast fibers contain M-protein while M-bands in slow fibers contain a significant proportion of the EH-myomesin isoform, previously detected only in embryonic heart muscle. This fiber-type specificity develops during the first postnatal weeks. However, the ratio between the amounts of myosin and of myomesin, taken as sum of both isoforms, remains nearly constant in all studied muscles. Ultrastructural analysis demonstrates that some of the soleus fibers show a diffuse appearance of the M-band, resembling the situation in the embryonic heart. A model is proposed to explain the functional consequence of differential M-band composition for the physiological and morphological properties of sarcomeres in different muscle types.

sted, utgiver, år, opplag, sider
2004. Vol. 83, nr 5, s. 193-204
Emneord [en]
Animals, Hindlimb/chemistry/metabolism, Mice, Microscopy; Electron, Muscle Fibers/*chemistry/metabolism, Muscle Fibers; Slow-Twitch/chemistry/metabolism, Muscle Proteins/chemistry/genetics/metabolism, Muscle; Skeletal/chemistry/metabolism/ultrastructure, Protein Isoforms/chemistry/genetics/metabolism, Sarcomeres/*chemistry/metabolism
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URN: urn:nbn:se:umu:diva-12687PubMedID: 15346809OAI: oai:DiVA.org:umu-12687DiVA, id: diva2:152358
Tilgjengelig fra: 2007-11-30 Laget: 2007-11-30 Sist oppdatert: 2018-06-09bibliografisk kontrollert

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