Umeå University's logo

umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Lead-exposure associated miRNAs in humans and Alzheimer’s disease as potential biomarkers of the disease and disease processes
Department of Toxicogenomics, Maastricht University, Universiteitssingel 50, Maastricht, Netherlands; MHeNS, School for Mental Health and Neuroscience, Maastricht University, Universiteitssingel 50, Maastricht, Netherlands.
Department of Toxicogenomics, Maastricht University, Universiteitssingel 50, Maastricht, Netherlands; MHeNS, School for Mental Health and Neuroscience, Maastricht University, Universiteitssingel 50, Maastricht, Netherlands.
Department of Biomedical Sciences, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, Antwerpen, Belgium; Neuroprotection and Neuromodulation (NEUR), Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, Brussel, Belgium; Department of Neurology, and Brussels Integrated Center for Brain and Memory (Bru-BRAIN), Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, Brussel, Belgium.
Department of Toxicogenomics, Maastricht University, Universiteitssingel 50, Maastricht, Netherlands.
Vise andre og tillknytning
2022 (engelsk)Inngår i: Scientific Reports, E-ISSN 2045-2322, Vol. 12, nr 1, artikkel-id 15966Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Alzheimer’s disease (AD) is a neurodegenerative disease that eventually affects memory and behavior. The identification of biomarkers based on risk factors for AD provides insight into the disease since the exact cause of AD remains unknown. Several studies have proposed microRNAs (miRNAs) in blood as potential biomarkers for AD. Exposure to heavy metals is a potential risk factor for onset and development of AD. Blood cells of subjects that are exposed to lead detected in the circulatory system, potentially reflect molecular responses to this exposure that are similar to the response of neurons. In this study we analyzed blood cell-derived miRNAs derived from a general population as proxies of potentially AD-related mechanisms triggered by lead exposure. Subsequently, we analyzed these mechanisms in the brain tissue of AD subjects and controls. A total of four miRNAs were identified as lead exposure-associated with hsa-miR-3651, hsa-miR-150-5p and hsa-miR-664b-3p being negatively and hsa-miR-627 positively associated. In human brain derived from AD and AD control subjects all four miRNAs were detected. Moreover, two miRNAs (miR-3651, miR-664b-3p) showed significant differential expression in AD brains versus controls, in accordance with the change direction of lead exposure. The miRNAs’ gene targets were validated for expression in the human brain and were found enriched in AD-relevant pathways such as axon guidance. Moreover, we identified several AD relevant transcription factors such as CREB1 associated with the identified miRNAs. These findings suggest that the identified miRNAs are involved in the development of AD and might be useful in the development of new, less invasive biomarkers for monitoring of novel therapies or of processes involved in AD development.

sted, utgiver, år, opplag, sider
Nature Publishing Group, 2022. Vol. 12, nr 1, artikkel-id 15966
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-200102DOI: 10.1038/s41598-022-20305-5PubMedID: 36153426Scopus ID: 2-s2.0-85138460597OAI: oai:DiVA.org:umu-200102DiVA, id: diva2:1703201
Tilgjengelig fra: 2022-10-12 Laget: 2022-10-12 Sist oppdatert: 2022-10-12bibliografisk kontrollert

Open Access i DiVA

fulltext(2082 kB)91 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 2082 kBChecksum SHA-512
2ddf352206a2c3f368006234875098a59b01cb23051917448303e2e20c15bf3ebdda388e42a17e675c89a78ea94b2ca30fc3cbf56cb43beb06c71640f039fbba
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMedScopus

Person

Bergdahl, Ingvar

Søk i DiVA

Av forfatter/redaktør
Bergdahl, Ingvar
Av organisasjonen
I samme tidsskrift
Scientific Reports

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 91 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 201 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf