Umeå University's logo

umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Associations of PFAS-related plasma metabolites with cholesterol and triglyceride concentrations
Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Avdelningen för hållbar hälsa.ORCID-id: 0000-0003-1227-6859
Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden; Department of Life Technologies, University of Turku, Turku, Finland; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden; School of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’ an, China.
Vise andre og tillknytning
2023 (engelsk)Inngår i: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 216, artikkel-id 114570Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The wide-spread environmental pollutants per- and polyfluoroalkyl substances (PFAS) have repeatedly been associated with elevated serum cholesterol in humans. However, underlying mechanisms are still unclear. Furthermore, we have previously observed inverse associations with plasma triglycerides. To better understand PFAS-induced effects on lipid pathways we investigated associations of PFAS-related metabolite features with plasma cholesterol and triglyceride concentrations. We used 290 PFAS-related metabolite features that we previously discovered from untargeted liquid chromatography-mass spectometry metabolomics in a case-control study within the Swedish Västerbotten Intervention Programme cohort. Herein, we studied associations of these PFAS-related metabolite features with plasma cholesterol and triglyceride concentrations in plasma samples from 187 healthy control subjects collected on two occasions between 1991 and 2013. The PFAS-related features did not associate with cholesterol, but 50 features were associated with triglycerides. Principal component analysis on these features indicated that one metabolite pattern, dominated by glycerophospholipids, correlated with longer chain PFAS and associated inversely with triglycerides (both cross-sectionally and prospectively), after adjustment for confounders. The observed time-trend of the metabolite pattern resembled that of the longer chain PFAS, with higher levels during the years 2004-2010. Mechanisms linking PFAS exposures to triglycerides may thus occur via longer chain PFAS affecting glycerophospholipid metabolism. If the results reflect a cause-effect association, as implied by the time-trend and prospective analyses, this may affect the general adult population.

sted, utgiver, år, opplag, sider
Elsevier, 2023. Vol. 216, artikkel-id 114570
Emneord [en]
Cholesterol, HBM4EU, Metabolomics, Per- and polyfluoroalkyl substances, Triglycerides
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-200731DOI: 10.1016/j.envres.2022.114570ISI: 000901257900002PubMedID: 36243049Scopus ID: 2-s2.0-85139821796OAI: oai:DiVA.org:umu-200731DiVA, id: diva2:1708222
Forskningsfinansiär
Swedish Research Council, 2018-05973Swedish Research Council, 2017-00650Swedish Research Council, 2017-00822Swedish Research Council, 2017-05840Swedish Research Council Formas, 2016-00314Swedish Research Council Formas, 2020-01653Forte, Swedish Research Council for Health, Working Life and Welfare, 2012-0758Dr P Håkanssons stiftelseEU, Horizon 2020, 733032Tilgjengelig fra: 2022-11-03 Laget: 2022-11-03 Sist oppdatert: 2023-09-05bibliografisk kontrollert

Open Access i DiVA

fulltext(3497 kB)141 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 3497 kBChecksum SHA-512
c53c52162763dd95b6000577a40e2c2900f920ef713d066f16fe693f9d9de87134816d5d4ca4e1ff67be4e345e826138ff1a610e76e3848d752bc91c254b1c43
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMedScopus

Person

Bergdahl, IngvarLandberg, Rikard

Søk i DiVA

Av forfatter/redaktør
Bergdahl, IngvarLandberg, Rikard
Av organisasjonen
I samme tidsskrift
Environmental Research

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 141 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 221 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf