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Renal effects evolution in a Chinese population after reduction of cadmium exposure in rice.
Umeå universitet, Medicinsk fakultet, Folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
Umeå universitet, Medicinsk fakultet, Folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
Vise andre og tillknytning
2008 (engelsk)Inngår i: Environmental research, ISSN 1096-0953, Vol. 108, nr 2, s. 233-8Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Cadmium is a well-known nephrotoxic agent with extremely long biological half-time of 10-30 years in human. To investigate the evolution of cadmium-induced renal effects in the population, a number of 148 residents who lived in cadmium-polluted area were followed-up for 3 years after the reduction of cadmium exposure in rice. Urinary cadmium (UCd), beta(2)-microglobulin (B2M) and albumin (ALB) were analyzed in 1995 and 1998, respectively. The results demonstrated that the changes of renal effects of residents depended on the levels of UCd before inflow of cadmium to human body declined. In cases where UCd were less than 10 microg/g creatinine in 1995, evidence was found indicating significant decreases in proteinuria (i.e., B2M and ALB) 3 years later, whereas, in cases where the excretion of UCd exceeded 10 microg/g creatinine in 1995, progression was observed. The study of dose-response relationships between UCd and B2M or ALB also showed that the cadmium-induced renal dysfunction might be reversible if UCd concentration was low-level before exposure decreasing, otherwise it might be irreversible or aggravated.

sted, utgiver, år, opplag, sider
2008. Vol. 108, nr 2, s. 233-8
Identifikatorer
URN: urn:nbn:se:umu:diva-18716DOI: 10.1016/j.envres.2008.02.011PubMedID: 18692183OAI: oai:DiVA.org:umu-18716DiVA, id: diva2:174639
Tilgjengelig fra: 2009-02-24 Laget: 2009-02-24 Sist oppdatert: 2018-06-09

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