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Polybrominated diphenyl ethers in type 2 diabetes mellitus cases and controls: Repeated measurements prior to and after diagnosis
Department of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromsø, Norway.
Department of Medical Biology, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromsø, Norway; Department of Laboratory Medicine, Division of Diagnostic Services, University Hospital of North Norway, Tromsø, Norway.
Department of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromsø, Norway; Department of Community Medicine and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromsø, Norway.
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2023 (engelsk)Inngår i: International journal of hygiene and environmental health, ISSN 1438-4639, E-ISSN 1618-131X, Vol. 249, artikkel-id 114148Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Previous studies have reported associations between certain persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM). Polybrominated diphenyl ethers (PBDEs) are a class of POPs that are found in increasing concentrations in humans. Although obesity is a known risk factor for T2DM and PBDEs are fat-soluble, very few studies have investigated associations between PBDEs and T2DM. No longitudinal studies have assessed associations between repeated measurements of PBDE and T2DM in the same individuals and compared time trends of PBDEs in T2DM cases and controls.

Objectives: To investigate associations between pre- and post-diagnostic measurements of PBDEs and T2DM and to compare time trends of PBDEs in T2DM cases and controls.

Methods: Questionnaire data and serum samples from participants in the Tromsø Study were used to conduct a longitudinal nested case-control study among 116 T2DM cases and 139 controls. All included study participants had three pre-diagnostic blood samples (collected before T2DM diagnosis in cases), and up to two post-diagnostic samples after T2DM diagnosis. We used logistic regression models to investigate pre- and post-diagnostic associations between PBDEs and T2DM, and linear mixed-effect models to assess time trends of PBDEs in T2DM cases and controls.

Results: We observed no substantial pre- or post-diagnostic associations between any of the PBDEs and T2DM, except for BDE-154 at one of the post-diagnostic time-points (OR = 1.65, 95% CI: 1.00, 2.71). The overall time trends of PBDE concentrations were similar for cases and controls.

Discussion: The study did not support PBDEs increasing the odds of T2DM, prior to or after T2DM diagnosis. T2DM status did not influence the time trends of PBDE concentrations.

sted, utgiver, år, opplag, sider
Elsevier, 2023. Vol. 249, artikkel-id 114148
Emneord [en]
Polybrominated diphenyl ethers, Pre- and post-diagnostic associations, Repeated measurements, Time trends, Type 2 diabetes mellitus
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Identifikatorer
URN: urn:nbn:se:umu:diva-205784DOI: 10.1016/j.ijheh.2023.114148ISI: 000955903500001PubMedID: 36881976Scopus ID: 2-s2.0-85149801578OAI: oai:DiVA.org:umu-205784DiVA, id: diva2:1746506
Tilgjengelig fra: 2023-03-28 Laget: 2023-03-28 Sist oppdatert: 2024-07-04bibliografisk kontrollert

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