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Maternal hormones during early pregnancy: a cross-sectional study
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Klinisk kemi.
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2010 (engelsk)Inngår i: Cancer Causes and Control, ISSN 0957-5243, E-ISSN 1573-7225, Vol. 21, nr 5, s. 719-727Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Little is known about correlates of first-trimester pregnancy hormones as in most studies maternal hormones have been measured later in gestation. We examined the associations of maternal characteristics and child sex with first-trimester maternal concentrations of four hormones implicated in breast cancer: human chorionic gonadotropin (hCG), alpha-fetoprotein (AFP), insulin-like growth factor (IGF)-I, and IGF-II. METHODS: About 338 serum samples donated to the Northern Sweden Maternity Cohort (NSMC), 1975-2001, during the first trimester of uncomplicated pregnancies, were analyzed for the hormones of interest as a part of a case-control study. The associations of maternal characteristics and child sex with hormone concentrations were investigated by correlation, general linear regression, and multivariate regression models. RESULTS: In the first trimester, greater maternal age was inversely correlated with IGF-I and IGF-II. In comparison with women carrying their first child, already parous women had higher IGF-I but lower hCG. Greater maternal weight and smoking were inversely correlated with hCG. No differences in hormone levels by child sex were observed. CONCLUSIONS: Our analyses indicated that potentially modifiable maternal characteristics (maternal weight and smoking) influence first-trimester pregnancy maternal hormone concentrations.

sted, utgiver, år, opplag, sider
2010. Vol. 21, nr 5, s. 719-727
Emneord [en]
Pregnancy, Cross-sectional study, Human chorionic gonadotropin (hCG), α-Fetoprotein (AFP), Insulin-like growth factor (IGF)-I, IGF-II
Identifikatorer
URN: urn:nbn:se:umu:diva-34561DOI: 10.1007/s10552-009-9500-2ISI: 000276768500008PubMedID: 20084544OAI: oai:DiVA.org:umu-34561DiVA, id: diva2:322837
Tilgjengelig fra: 2010-06-08 Laget: 2010-06-08 Sist oppdatert: 2018-06-08bibliografisk kontrollert

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Lundin, EvaGrankvist, KjellWulff, MarianneJohansson, RobertLenner, PerHallmans, GöranWadell, Göran

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