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Catch-Bond behavior of bacteria binding by slip bonds
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för fysik.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för fysik.
2010 (engelsk)Inngår i: Biophysical Journal, ISSN 0006-3495, E-ISSN 1542-0086, Vol. 99, nr 5, s. 1331-1341Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

It is shown that multipili-adhering bacteria expressing helix-like pili binding by slip bonds can show catch-bond behavior. When exposed to an external force, such bacteria can mediate adhesion to their hosts by either of two limiting means: sequential or simultaneous pili force exposure (referring to when the pili mediate force in a sequential or simultaneous manner, respectively). As the force is increased, the pili can transition from sequential to simultaneous pili force exposure. Since the latter mode of adhesion gives rise to a significantly longer bacterial adhesion lifetime than the former, this results in a prolongation of the lifetime, which shows up as a catch-bond behavior. The properties and conditions of this effect were theoretically investigated and assessed in some detail for dual-pili-adhering bacteria, by both analytical means and simulations. The results indicate that the adhesion lifetime of such bacteria can be prolonged by more than an order of magnitude. This implies that the adhesion properties of multibinding systems cannot be directly conveyed to the individual adhesion-receptor bonds.

sted, utgiver, år, opplag, sider
2010. Vol. 99, nr 5, s. 1331-1341
Emneord [en]
Catch bond, slip bond, multipili, cooperative, binding, bacterium, adhesion, in vivo
HSV kategori
Forskningsprogram
fysikalisk biologi
Identifikatorer
URN: urn:nbn:se:umu:diva-36157DOI: 10.1016/j.bpj.2010.06.003ISI: 000281721500002OAI: oai:DiVA.org:umu-36157DiVA, id: diva2:352421
Tilgjengelig fra: 2010-09-21 Laget: 2010-09-21 Sist oppdatert: 2018-06-08bibliografisk kontrollert

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